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BioAssay: AID 612451

Activation of androgen receptor in androgen-sensitive (AR+) mouse Shionogi cells assessed as stimulation of cell proliferation after 10 days at 1 uM relative to control

17Beta-hydroxysteroid dehydrogenase type 3 (17I(2)-HSD3) is a steroidogenic enzyme that catalyzes the transformation of 4-androstene-3,17-dione (I ..more
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 Tested Compounds
 Tested Compounds
All(4)
 
 
Inactive(2)
 
 
Unspecified(2)
 
 
 Tested Substances
 Tested Substances
All(4)
 
 
Inactive(2)
 
 
Unspecified(2)
 
 
 Related BioAssays
 Related BioAssays
AID: 612451
Data Source: ChEMBL (762462)
Depositor Category: Literature, Extracted
BioAssay Version:
Deposit Date: 2012-04-30
Modify Date: 2014-08-24

Data Table ( Complete ):           View All Data
Target
Sequence: RecName: Full=Androgen receptor; AltName: Full=Dihydrotestosterone receptor; AltName: Full=Nuclear receptor subfamily 3 group C member 4
Description ..   
Protein Family: Ligand binding domain of the nuclear receptor androgen receptor, ligand activated transcription regulator
Comment ..   

Gene:AR     Related Protein 3D Structures     More BioActivity Data..
Tested Compounds:
Description:
Title: Development of 3-substituted-androsterone derivatives as potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 3.

Abstract: 17Beta-hydroxysteroid dehydrogenase type 3 (17I(2)-HSD3) is a steroidogenic enzyme that catalyzes the transformation of 4-androstene-3,17-dione (I
(PMID: 21741247)
Categorized Comment - additional comments and annotations
From BioAssay Depositor:
Assay Type: Binding
Target Type: Target is a single protein chain
Assay Data Source: Scientific Literature
Result Definitions
TIDNameDescriptionHistogramTypeUnit
OutcomeThe BioAssay activity outcomeOutcome
1Activity activity commentActivity activity commentString
2Activity standard flagActivity standard flagInteger
3Activity qualifierActivity qualifierString
4Activity published valueActivity published valueFloat%
5Activity standard valueActivity standard valueFloat%

Data Table (Concise)
Data Table ( Complete ):     View All Data
Classification
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