Displacement of [125I]ABN from human recombinant D3 receptor expressed in HEK cells after 60 mins by gamma counter - BioAssay Summary
A series of compounds structurally related to aripiprazole (1), an atypical antipsychotic and antidepressant used clinically for the treatment of schizophrenia, bipolar disorder, and depression, have been prepared and evaluated for affinity at D(# ..more
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 Tested Compounds
 Tested Compounds
All(16)
 
 
Active(16)
 
 
 Tested Substances
 Tested Substances
All(16)
 
 
Active(16)
 
 
 Related BioAssays
 Related BioAssays
Table of Contents
AID: 610679
Data Source: ChEMBL (760690)
Depositor Category: Literature, Extracted
BioAssay Version:
Deposit Date: 2012-04-30
Modify Date: 2013-05-15

Data Table (Complete):           Active    All
Target
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Sequence: RecName: Full=D(3) dopamine receptor; AltName: Full=Dopamine D3 receptor
Description ..   
Comment ..   

Gene:DRD3     Conserved Domain     Related Protein 3D Structures
BioActive Compounds: 16
Description:
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Title: Synthesis and characterization of selective dopamine D#

Abstract: A series of compounds structurally related to aripiprazole (1), an atypical antipsychotic and antidepressant used clinically for the treatment of schizophrenia, bipolar disorder, and depression, have been prepared and evaluated for affinity at D(#
(PMID: 21536445)
Comment
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Compounds with activity <= 50uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Categorized Comment
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ChEMBL Assay Type: Binding

ChEMBL Assay Data Source: Scientific Literature

ChEMBL Target ID: 130

ChEMBL target type: Target is a single protein chain

Result Definitions
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TIDNameDescriptionHistogramTypeUnit
OutcomeThe BioAssay activity outcomeOutcome
1Ki*Ki PubChem standard valueFloatμM
2BEIBinding Efficiency Index(nM)Float
3SEISurface Efficiency Index(nM)Float
4Ki activity commentKi activity commentString
5Ki standard flagKi standard flagInteger
6Ki qualifierKi qualifierString
7Ki published valueKi published valueFloatnM
8Ki standard valueKi standard valueFloatnM
9Ki binding domainsKi binding domainsString
* Activity Concentration.

Data Table (Concise)
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Classification
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