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BioAssay: AID 600456

Partial agonist activity at PPARdelta

Title: Improvement in aqueous solubility in small molecule drug discovery programs by disruption of molecular planarity and symmetry.
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 Tested Compounds
 Tested Compounds
All(8)
 
 
Active(8)
 
 
 Tested Substances
 Tested Substances
All(8)
 
 
Active(8)
 
 
 Related BioAssays
 Related BioAssays
AID: 600456
Data Source: ChEMBL (750607)
Depositor Category: Literature, Extracted
BioAssay Version:
Deposit Date: 2012-02-15
Modify Date: 2013-11-17

Data Table ( Complete ):           Active    All
BioActive Compounds: 8
Description:
Title: Improvement in aqueous solubility in small molecule drug discovery programs by disruption of molecular planarity and symmetry.
(PMID: 21344906)
Comment
Compounds with activity <= 50uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Putative Target:

ChEMBL Target ID: 12227
Target Type: SINGLE PROTEIN
Pref Name: Peroxisome proliferator-activated receptor delta
Synonyms: NUC1;NUCI;Nuclear hormone receptor 1;Nuclear receptor subfamily 1 group C member 2;Peroxisome proliferator-activated receptor beta;Peroxisome proliferator-activated receptor delta;PPAR-beta;PPAR-delta;
Gene Name: NR1C2 ;PPARB;PPARD;
Protein Accession: Q03181;
Protein GI: 417522;
Organism: Homo sapiens
Tax ID: 9606
Target Classification: transcription factor nuclear receptor nr1 nr1c nr1c2
Confidence: Homologous single protein target assigned
Relationship Type: Homologous protein target assigned
Categorized Comment
ChEMBL Assay Type: Functional

ChEMBL Assay Data Source: Scientific Literature

Result Definitions
TIDNameDescriptionHistogramTypeUnit
OutcomeThe BioAssay activity outcomeOutcome
1EC50*EC50 PubChem standard valueFloatμM
2EC50 activity commentEC50 activity commentString
3EC50 standard flagEC50 standard flagInteger
4EC50 qualifierEC50 qualifierString
5EC50 published valueEC50 published valueFloatnM
6EC50 standard valueEC50 standard valueFloatnM

* Activity Concentration.

Data Table (Concise)
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