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BioAssay: AID 600449

Antagonist activity at alphavbeta3 integrin receptor

Title: Improvement in aqueous solubility in small molecule drug discovery programs by disruption of molecular planarity and symmetry.
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 Tested Compounds
 Tested Compounds
All(11)
 
 
Active(11)
 
 
 Tested Substances
 Tested Substances
All(11)
 
 
Active(11)
 
 
 Related BioAssays
 Related BioAssays
AID: 600449
Data Source: ChEMBL (750600)
BioAssay Type: Confirmatory, Concentration-Response Relationship Observed
Depositor Category: Literature, Extracted
BioAssay Version:
Deposit Date: 2012-02-15
Modify Date: 2014-05-25

Data Table ( Complete ):           View Active Data    View All Data
BioActive Compounds: 11
Description:
Title: Improvement in aqueous solubility in small molecule drug discovery programs by disruption of molecular planarity and symmetry.
(PMID: 21344906)
Comment
Compounds with activity <= 50uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Putative Target:

ChEMBL Target ID: 104292
Target Type: PROTEIN COMPLEX
Pref Name: Integrin alpha-V/beta-3
Synonyms: CD_antigen=CD61;GPIIIa;Integrin beta-3;Platelet membrane glycoprotein IIIa;CD_antigen=CD51;Integrin alpha-V;Integrin alpha-V heavy chain;Integrin alpha-V light chain;Vitronectin receptor subunit alpha;
Gene Name: GP3A;ITGB3;ITGAV;MSK8 ;VNRA;
Protein Accession: P05106;P06756;
Protein GI: 125987835;143811408;
Organism: Homo sapiens
Tax ID: 9606
Target Classification: membrane receptor
Confidence: Homologous protein complex subunits assigned
Relationship Type: Homologous protein target assigned
Categorized Comment
Assay Type: Functional

Assay Data Source: Scientific Literature

Result Definitions
TIDNameDescriptionHistogramTypeUnit
OutcomeThe BioAssay activity outcomeOutcome
1IC50*IC50 PubChem standard valueFloatμM
2IC50 activity commentIC50 activity commentString
3IC50 standard flagIC50 standard flagInteger
4IC50 qualifierIC50 qualifierString
5IC50 published valueIC50 published valueFloatnM
6IC50 standard valueIC50 standard valueFloatnM

* Activity Concentration.

Data Table (Concise)
Data Table ( Complete ):     View Active Data    View All Data
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