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BioAssay: AID 570626

Inhibition of human recombinant cathepsin S after 1 hr

Inhibition of human recombinant cathepsin S after 1 hr ..more
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 Tested Compounds
 Tested Compounds
All(17)
 
 
Active(14)
 
 
Unspecified(3)
 
 
 Tested Substances
 Tested Substances
All(17)
 
 
Active(14)
 
 
Unspecified(3)
 
 
 Related BioAssays
 Related BioAssays
AID: 570626
Data Source: ChEMBL (719166)
BioAssay Type: Confirmatory, Concentration-Response Relationship Observed
Depositor Category: Literature, Extracted
BioAssay Version:
Deposit Date: 2011-09-18
Modify Date: 2014-05-27

Data Table ( Complete ):           Active    All
Target
Sequence: RecName: Full=Cathepsin S; Flags: Precursor
Description ..   
Protein Family: Peptidase_C1A
Comment ..   

Gene:CTSS     Related Protein 3D Structures     More BioActivity Data..
BioActive Compounds: 14
Description:
Inhibition of human recombinant cathepsin S after 1 hr
Comment
Compounds with activity <= 50uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.



Publication:
Journal: ACS Med. Chem. Lett.
Year: 2011
Volume: 2
Issue: 2
First Page: 142
Last Page: 147
Categorized Comment
Assay Type: Binding

Assay Data Source: Scientific Literature

BAO: Assay Format: biochemical format

Target Type: Target is a single protein chain

Result Definitions
Show more
TIDNameDescriptionHistogramTypeUnit
OutcomeThe BioAssay activity outcomeOutcome
1IC50*IC50 PubChem standard valueFloatμM
3BEIBinding Efficiency Index(nM)Float
2SEISurface Efficiency Index(nM)Float
4LELigand EfficiencyFloat
5LLELipophilic Ligand EfficiencyFloat
6IC50 activity commentIC50 activity commentString
7IC50 standard flagIC50 standard flagInteger
8IC50 qualifierIC50 qualifierString
9IC50 published valueIC50 published valueFloat
10IC50 standard valueIC50 standard valueFloatnM
11IC50 binding domainsIC50 binding domainsString

* Activity Concentration.

Data Table (Concise)
Classification
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