Bookmark and Share
BioAssay: AID 553586

Agonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to control

Agonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to control ..more
_
   
 Tested Compounds
 Tested Compounds
All(12)
 
 
Active(5)
 
 
Inactive(7)
 
 
 Tested Substances
 Tested Substances
All(12)
 
 
Active(5)
 
 
Inactive(7)
 
 
 Related BioAssays
 Related BioAssays
AID: 553586
Data Source: ChEMBL (702114)
Depositor Category: Literature, Extracted
BioAssay Version:
Deposit Date: 2011-09-18
Modify Date: 2013-11-17

Data Table ( Complete ):           Active    All
Target
Sequence: RecName: Full=Follicle-stimulating hormone receptor; Short=FSH-R; AltName: Full=Follitropin receptor; Flags: Precursor
Description ..   
Protein Family: Gonadotropin hormone receptor transmembrane region
Comment ..   

Gene:FSHR     Related Protein 3D Structures     More BioActivity Data..
BioActive Compounds: 5
Description:
Agonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to control
Comment
Compounds with activity <= 50uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.



Publication:
Journal: ACS Med. Chem. Lett.
Year: 2011
Volume: 2
Issue: 1
First Page: 85
Last Page: 89
Categorized Comment
ChEMBL Assay Type: Functional

ChEMBL Assay Data Source: Scientific Literature

ChEMBL Assay Cell Type: CHO-K1

ChEMBL Target ID: 99

ChEMBL Target Type: Target is a single protein chain

Result Definitions
TIDNameDescriptionHistogramTypeUnit
OutcomeThe BioAssay activity outcomeOutcome
1IC50*IC50 PubChem standard valueFloatμM
2IC50 activity commentIC50 activity commentString
3IC50 standard flagIC50 standard flagInteger
4IC50 qualifierIC50 qualifierString
5IC50 published valueIC50 published valueFloatnM
6IC50 standard valueIC50 standard valueFloatnM
7IC50 binding domainsIC50 binding domainsString

* Activity Concentration.

Data Table (Concise)
Classification
PageFrom: