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BioAssay: AID 527455

Binding affinity to human Hsc70 by isothermal calorimetry assay

Title: ATPases as drug targets: insights from heat shock proteins 70 and 90.
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 Tested Compounds
 Tested Compounds
All(1)
 
 
Active(1)
 
 
 Tested Substances
 Tested Substances
All(1)
 
 
Active(1)
 
 
 Related BioAssays
 Related BioAssays
AID: 527455
Data Source: ChEMBL (675336)
BioAssay Type: Confirmatory, Concentration-Response Relationship Observed
Depositor Category: Literature, Extracted
BioAssay Version:
Deposit Date: 2011-09-18
Modify Date: 2014-08-23

Data Table ( Complete ):           View Active Data    View All Data
BioActive Compound: 1
Description:
Title: ATPases as drug targets: insights from heat shock proteins 70 and 90.
(PMID: 20608738)
Comment
Compounds with activity <= 50uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Putative Target:

ChEMBL Target ID: 103588
Target Type: SINGLE PROTEIN
Pref Name: Heat shock cognate 71 kDa protein
Synonyms: Heat shock 70 kDa protein 8;Heat shock cognate 71 kDa protein;LAP-1;Lipopolysaccharide-associated protein 1;LPS-associated protein 1;
Gene Name: HSC70 ;HSP73;HSPA10;HSPA8;
Protein Accession: P11142;
Protein GI: 123648;
Organism: Homo sapiens
Tax ID: 9606
Target Classification: unclassified
Confidence: Homologous single protein target assigned
Relationship Type: Homologous protein target assigned
Categorized Comment - additional comments and annotations
From BioAssay Depositor:
Assay Type: Binding
Assay Data Source: Scientific Literature
Result Definitions
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TIDNameDescriptionHistogramTypeUnit
OutcomeThe BioAssay activity outcomeOutcome
1Kd*Kd PubChem standard valueFloatμM
3BEIBinding Efficiency Index(nM)Float
2SEISurface Efficiency Index(nM)Float
4LELigand EfficiencyFloat
5LLELipophilic Ligand EfficiencyFloat
6Kd activity commentKd activity commentString
7Kd standard flagKd standard flagInteger
8Kd qualifierKd qualifierString
9Kd published valueKd published valueFloatnM
10Kd standard valueKd standard valueFloatnM

* Activity Concentration.

Data Table (Concise)
Data Table ( Complete ):     View Active Data    View All Data
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