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BioAssay: AID 463630

Inhibition of wild type Bcr-Abl

Title: Selectively nonselective kinase inhibition: striking the right balance.
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 Tested Compounds
 Tested Compounds
All(6)
 
 
Active(6)
 
 
 Tested Substances
 Tested Substances
All(6)
 
 
Active(6)
 
 
 Related BioAssays
 Related BioAssays
AID: 463630
Data Source: ChEMBL (614493)
BioAssay Type: Confirmatory, Concentration-Response Relationship Observed
Depositor Category: Literature, Extracted
BioAssay Version:
Deposit Date: 2010-09-27
Modify Date: 2014-05-24

Data Table ( Complete ):           Active    All
BioActive Compounds: 6
Description:
Title: Selectively nonselective kinase inhibition: striking the right balance.
(PMID: 20166671)
Comment
Compounds with activity <= 50uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Putative Target:

ChEMBL Target ID: 104811
Target Type: CHIMERIC PROTEIN
Pref Name: Bcr/Abl fusion protein
Synonyms: Abelson murine leukemia viral oncogene homolog 1;Abelson tyrosine-protein kinase 1;p150;Proto-oncogene c-Abl;Tyrosine-protein kinase ABL1;Breakpoint cluster region protein;Renal carcinoma antigen NY-REN-26;
Gene Name: ABL ;ABL1;JTK7;BCR;BCR1 ;D22S11;
Protein Accession: P00519;P11274;
Protein GI: 85681908;143811366;
Organism: Homo sapiens
Tax ID: 9606
Target Classification 1: cytosolic other
Target Classification 2: enzyme kinase protein kinase atypical bcr
Target Classification 3: enzyme kinase protein kinase tk abl
Confidence: Homologous protein complex subunits assigned
Relationship Type: Homologous protein target assigned
Categorized Comment
Assay Type: Binding

Assay Data Source: Scientific Literature

BAO: Assay Format: biochemical format

Result Definitions
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TIDNameDescriptionHistogramTypeUnit
OutcomeThe BioAssay activity outcomeOutcome
1IC50*IC50 PubChem standard valueFloatμM
3BEIBinding Efficiency Index(nM)Float
2SEISurface Efficiency Index(nM)Float
4LELigand EfficiencyFloat
5LLELipophilic Ligand EfficiencyFloat
6IC50 activity commentIC50 activity commentString
7IC50 standard flagIC50 standard flagInteger
8IC50 qualifierIC50 qualifierString
9IC50 published valueIC50 published valueFloatnM
10IC50 standard valueIC50 standard valueFloatnM
11IC50 activity commentIC50 activity commentString
12IC50 standard flagIC50 standard flagInteger
13IC50 qualifierIC50 qualifierString
14IC50 published valueIC50 published valueFloatμM
15IC50 standard valueIC50 standard valueFloatnM

* Activity Concentration.

Data Table (Concise)
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