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BioAssay: AID 463630

Inhibition of wild type Bcr-Abl

Title: Selectively nonselective kinase inhibition: striking the right balance.
 Tested Compounds
 Tested Compounds
 Tested Substances
 Tested Substances
 Related BioAssays
 Related BioAssays
AID: 463630
Data Source: ChEMBL (614493)
BioAssay Type: Confirmatory, Concentration-Response Relationship Observed
Depositor Category: Literature, Extracted
BioAssay Version:
Deposit Date: 2010-09-27
Modify Date: 2015-06-04

Data Table ( Complete ):           View Active Data    View All Data
BioActive Compounds: 6
Title: Selectively nonselective kinase inhibition: striking the right balance.
(PMID: 20166671)
Compounds with activity <= 50uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Putative Target:

ChEMBL Target ID: 104811
Pref Name: Bcr/Abl fusion protein
Synonyms: Abelson murine leukemia viral oncogene homolog 1;Abelson tyrosine-protein kinase 1;p150;Proto-oncogene c-Abl;Tyrosine-protein kinase ABL1;Breakpoint cluster region protein;Renal carcinoma antigen NY-REN-26;
Gene Name: ABL ;ABL1;JTK7;BCR;BCR1 ;D22S11;
Protein Accession: P00519;P11274;
Protein GI: 85681908;143811366;
Organism: Homo sapiens
Tax ID: 9606
Target Classification 1: cytosolic other
Target Classification 2: enzyme kinase protein kinase atypical bcr
Target Classification 3: enzyme kinase protein kinase tk abl
Confidence: Homologous protein complex subunits assigned
Relationship Type: Homologous protein target assigned
Categorized Comment - additional comments and annotations
From BioAssay Depositor:
Assay Type: Binding
Assay Data Source: Scientific Literature
Result Definitions
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OutcomeThe BioAssay activity outcomeOutcome
1IC50*IC50 PubChem standard valueFloatμM
3BEIBinding Efficiency Index(nM)Float
2SEISurface Efficiency Index(nM)Float
4LELigand EfficiencyFloat
5LLELipophilic Ligand EfficiencyFloat
6IC50 activity commentIC50 activity commentString
7IC50 standard flagIC50 standard flagInteger
8IC50 qualifierIC50 qualifierString
9IC50 published valueIC50 published valueFloatμM
10IC50 standard valueIC50 standard valueFloatnM

* Activity Concentration.

Data Table (Concise)
Data Table ( Complete ):     View Active Data    View All Data