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BioAssay: AID 426825

Transcriptional activation of HSF1 in human HeLa cells assessed as granule formation treated 3 hrs before heat shock challenge by immunocytochemical staining

Chloro-oxime derivatives were investigated as novel small molecule chaperone amplifiers. Lead optimization led to the discovery of compounds that displayed potent HSF1 activation activity, significant cytoprotection in MG-132 stress, ER stress and PolyQ stress cell models (EC(50)<10 microM). ..more
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 Tested Compounds
 Tested Compounds
All(46)
 
 
Inactive(45)
 
 
Unspecified(1)
 
 
 Tested Substances
 Tested Substances
All(48)
 
 
Inactive(47)
 
 
Unspecified(1)
 
 
 Related BioAssays
 Related BioAssays
AID: 426825
Data Source: ChEMBL (578169)
Depositor Category: Literature, Extracted
BioAssay Version:
Deposit Date: 2010-05-26
Modify Date: 2014-05-16

Data Table ( Complete ):           All
Target
Sequence: RecName: Full=Heat shock factor protein 1; Short=HSF 1; AltName: Full=Heat shock transcription factor 1; Short=HSTF 1
Description ..   
Protein Family: Vertebrate heat shock transcription factor
Comment ..   

Gene:HSF1     Related Protein 3D Structures     More BioActivity Data..
Tested Compounds:
Description:
Title: Chloro-oxime derivatives as novel small molecule chaperone amplifiers.

Abstract: Chloro-oxime derivatives were investigated as novel small molecule chaperone amplifiers. Lead optimization led to the discovery of compounds that displayed potent HSF1 activation activity, significant cytoprotection in MG-132 stress, ER stress and PolyQ stress cell models (EC(50)<10 microM).
(PMID: 19398333)
Categorized Comment
Assay Type: Binding

Assay Data Source: Scientific Literature

BAO: Assay Format: cell-based format

Assay Cell Type: HeLa

Target Type: Target is a single protein chain

Result Definitions
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TIDNameDescriptionHistogramTypeUnit
OutcomeThe BioAssay activity outcomeOutcome
1AC50 activity commentAC50 activity commentString
2AC50 standard flagAC50 standard flagInteger
3AC50 qualifierAC50 qualifierString
4AC50 published valueAC50 published valueFloat%
5AC50 standard valueAC50 standard valueFloat%
6Activity activity commentActivity activity commentString
7Activity standard flagActivity standard flagInteger
8Activity qualifierActivity qualifierString
9Activity published valueActivity published valueFloat
10Activity standard valueActivity standard valueFloat

Data Table (Concise)
Classification
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