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BioAssay: AID 426825

Transcriptional activation of HSF1 in human HeLa cells assessed as granule formation treated 3 hrs before heat shock challenge by immunocytochemical staining

Chloro-oxime derivatives were investigated as novel small molecule chaperone amplifiers. Lead optimization led to the discovery of compounds that displayed potent HSF1 activation activity, significant cytoprotection in MG-132 stress, ER stress and PolyQ stress cell models (EC(50)<10 microM). ..more
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 Tested Compounds
 Tested Compounds
All(46)
 
 
Inactive(45)
 
 
Unspecified(1)
 
 
 Tested Substances
 Tested Substances
All(46)
 
 
Inactive(45)
 
 
Unspecified(1)
 
 
 Related BioAssays
 Related BioAssays
AID: 426825
Data Source: ChEMBL (578169)
Depositor Category: Literature, Extracted
BioAssay Version:
Deposit Date: 2010-05-26
Modify Date: 2015-04-12

Data Table ( Complete ):           View All Data
Target
Sequence: RecName: Full=Heat shock factor protein 1; Short=HSF 1; AltName: Full=Heat shock transcription factor 1; Short=HSTF 1
Description ..   
Protein Family: Vertebrate heat shock transcription factor
Comment ..   

Gene:HSF1     Related Protein 3D Structures     More BioActivity Data..
Tested Compounds:
Description:
Title: Chloro-oxime derivatives as novel small molecule chaperone amplifiers.

Abstract: Chloro-oxime derivatives were investigated as novel small molecule chaperone amplifiers. Lead optimization led to the discovery of compounds that displayed potent HSF1 activation activity, significant cytoprotection in MG-132 stress, ER stress and PolyQ stress cell models (EC(50)<10 microM).
(PMID: 19398333)
Categorized Comment - additional comments and annotations
From BioAssay Depositor:
Assay Type: Binding
Target Type: Target is a single protein chain
Assay Data Source: Scientific Literature
BAO: Assay Format: cell-based format
Assay Cell Type: HeLa
Result Definitions
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TIDNameDescriptionHistogramTypeUnit
OutcomeThe BioAssay activity outcomeOutcome
1AC50 activity commentAC50 activity commentString
2AC50 standard flagAC50 standard flagInteger
3AC50 qualifierAC50 qualifierString
4AC50 published valueAC50 published valueFloat%
5AC50 standard valueAC50 standard valueFloat%
6AC50 data validityAC50 data validityString
7Activity activity commentActivity activity commentString
8Activity standard flagActivity standard flagInteger
9Activity qualifierActivity qualifierString
10Activity published valueActivity published valueFloat
11Activity standard valueActivity standard valueFloat
12Activity data validityActivity data validityString

Data Table (Concise)
Data Table ( Complete ):     View All Data
Classification
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