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BioAssay: AID 418172

Antiparasitic activity against Eimeria tenella at 50 ppm administered orally through feed after 7 days

Novel 2,3-diarylindoles bearing an amine substituent at the indole 5- and 6-positions have been synthesized and evaluated as anticoccidial agents in both in vitro and in vivo assays. Both subnanomolar in vitro activity and broad spectrum in vivo potency were detected for several compounds, particularly compound 27. ..more
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 Tested Compounds
 Tested Compounds
All(16)
 
 
Unspecified(16)
 
 
 Tested Substances
 Tested Substances
All(16)
 
 
Unspecified(16)
 
 
 Related BioAssays
 Related BioAssays
AID: 418172
Data Source: ChEMBL (566201)
Depositor Category: Literature, Extracted
BioAssay Version:
Deposit Date: 2010-05-26
Modify Date: 2014-05-16

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Tested Compounds:
Description:
Title: Synthesis and biological activity of anticoccidial agents: 2,3-diarylindoles.

Abstract: Novel 2,3-diarylindoles bearing an amine substituent at the indole 5- and 6-positions have been synthesized and evaluated as anticoccidial agents in both in vitro and in vivo assays. Both subnanomolar in vitro activity and broad spectrum in vivo potency were detected for several compounds, particularly compound 27.
(PMID: 19195883)
Comment
Putative Target:
ChEMBL Target ID: 50423
Target Type: ORGANISM
Pref Name: Eimeria tenella
Organism: Eimeria tenella
Tax ID: 5802
Confidence: Target assigned is non-molecular
Relationship Type: Non-molecular target assigned
Categorized Comment - additional comments and annotations
From ChEMBL:
Assay Type: Functional
Assay Data Source: Scientific Literature
BAO: Assay Format: organism-based format
Result Definitions
TIDNameDescriptionHistogramTypeUnit
OutcomeThe BioAssay activity outcomeOutcome
1Activity activity commentActivity activity commentString
2Activity standard flagActivity standard flagInteger
3Activity qualifierActivity qualifierString
4Activity published valueActivity published valueFloat%
5Activity standard valueActivity standard valueFloat%

Data Table (Concise)
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