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BioAssay: AID 40936

Inhibition of Bacillus subtilis PCI219 spore germination, expressed as log 1/I50

Phenols and fatty acids were found to inhibit L-alanine-initiated germination of Bacillus subtilis spores without altering their heat resistance. Inhibitory effect was defined as the concentration necessary to cause 50% inhibition of the germination rate. The quantitative structure-inhibitory activity relationships for 39 phenols and 7 fatty acids were analyzed. The pH dependency of inhibition more ..
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 Tested Compounds
 Tested Compounds
All(47)
 
 
Unspecified(47)
 
 
 Tested Substances
 Tested Substances
All(47)
 
 
Unspecified(47)
 
 
 Related BioAssays
 Related BioAssays
AID: 40936
Data Source: ChEMBL (38068)
Depositor Category: Literature, Extracted
BioAssay Version:
Deposit Date: 2010-05-21
Modify Date: 2014-05-19

Data Table ( Complete ):           View All Data
Tested Compounds:
Description:
Title: Quantitative structure-inhibitory activity relationships of phenols and fatty acids for Bacillus subtilis spore germination.

Abstract: Phenols and fatty acids were found to inhibit L-alanine-initiated germination of Bacillus subtilis spores without altering their heat resistance. Inhibitory effect was defined as the concentration necessary to cause 50% inhibition of the germination rate. The quantitative structure-inhibitory activity relationships for 39 phenols and 7 fatty acids were analyzed. The pH dependency of inhibition showed that the nonionized form of the molecule was responsible for inhibition. Hydrophobicity, which was expressed by the partition coefficient or the distribution coefficient of the compounds, was important for inhibition. In addition to hydrophobicity, the electronic effect, which was expressed by the dissociation constant, played a partial role in phenols. The correlation equation of the fatty acids was similar to those of the alcohols and other hydrophobic compounds, which had been reported earlier. That of the phenols, however, appeared to be different, indicating a different and more complex mechanism of inhibition. The type of inhibition by both compounds was mixed rather than competitive or noncompetitive.
(PMID: 6802973)
Comment
Putative Target:
ChEMBL Target ID: 50278
Target Type: ORGANISM
Pref Name: Bacillus subtilis
Organism: Bacillus subtilis
Tax ID: 1423
Confidence: Target assigned is non-molecular
Relationship Type: Non-molecular target assigned
Categorized Comment - additional comments and annotations
From ChEMBL:
Assay Type: Functional
Assay Data Source: Scientific Literature
BAO: Assay Format: organism-based format
Result Definitions
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TIDNameDescriptionHistogramTypeUnit
OutcomeThe BioAssay activity outcomeOutcome
1IC50 activity commentIC50 activity commentString
2IC50 standard flagIC50 standard flagInteger
3IC50 qualifierIC50 qualifierString
4IC50 published valueIC50 published valueFloat1/M
5IC50 standard valueIC50 standard valueFloat1/M
6IC50 data validityIC50 data validityString
7pIC50 activity commentpIC50 activity commentString
8pIC50 standard flagpIC50 standard flagInteger
9pIC50 qualifierpIC50 qualifierString
10pIC50 published valuepIC50 published valueFloat
11pIC50 standard valuepIC50 standard valueFloat
12pIC50 data validitypIC50 data validityString

Data Table (Concise)
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