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BioAssay: AID 40935

Inhibition of Bacillus subtilis spore germination, activity is expressed as log of the reciprocal of Casida's I50 value.

Ion-sensitive electrode potentiometry is proposed for determination of substituent constants for structural modifications of organic acids. A liquid membrane anion-sensitive electrode responds reproducibly to a wide range of carboxylate and sulfonate ions. Fragment constants for the addition of a methylene group to aromatic and aliphatic acids are -2.4 and -3.3 +/- 0.15 kJ/mol, respectively. more ..
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 Tested Compounds
 Tested Compounds
All(7)
 
 
Unspecified(7)
 
 
 Tested Substances
 Tested Substances
All(7)
 
 
Unspecified(7)
 
 
 Related BioAssays
 Related BioAssays
AID: 40935
Data Source: ChEMBL (38067)
BioAssay Type: Confirmatory, Concentration-Response Relationship Observed
Depositor Category: Literature, Extracted
BioAssay Version:
Deposit Date: 2010-05-21
Modify Date: 2014-05-19

Data Table ( Complete ):           All
Tested Compounds:
Description:
Title: Ion-sensitive electrode potentiometry of organic anions: application to quantitative structure-activity relationships.

Abstract: Ion-sensitive electrode potentiometry is proposed for determination of substituent constants for structural modifications of organic acids. A liquid membrane anion-sensitive electrode responds reproducibly to a wide range of carboxylate and sulfonate ions. Fragment constants for the addition of a methylene group to aromatic and aliphatic acids are -2.4 and -3.3 +/- 0.15 kJ/mol, respectively. Agreement is observed between these constants and those determined by other techniques, including partitioning studies in biphasic systems, suggesting the use of potentiometry for quantitative structure-activity relationship studies. Furthermore, the electrode measurements correlate with biological effects resulting from hydrophobic interactions.
(PMID: 6887198)
Comment
Putative Target:

ChEMBL Target ID: 50278
Target Type: ORGANISM
Pref Name: Bacillus subtilis
Organism: Bacillus subtilis
Tax ID: 1423
Confidence: Target assigned is non-molecular
Relationship Type: Non-molecular target assigned
Categorized Comment
Assay Type: Functional

Assay Data Source: Scientific Literature

BAO: Assay Format: organism-based format

Result Definitions
TIDNameDescriptionHistogramTypeUnit
OutcomeThe BioAssay activity outcomeOutcome
1IC50*IC50 PubChem standard valueFloatμM
2IC50 activity commentIC50 activity commentString
3IC50 standard flagIC50 standard flagInteger
4IC50 qualifierIC50 qualifierString
5IC50 published valueIC50 published valueFloat
6IC50 standard valueIC50 standard valueFloatnM
7IC50 data validityIC50 data validityString

* Activity Concentration.

Data Table (Concise)
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