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BioAssay: AID 379089

Growth inhibition of BALB/c mouse cloned 3T3/A31 cells after 72 hrs by nigrosin assay

Fourteen plant phenols of five structural groups (flavones, flavonols, flavan-3-ol, isoflavones, and phenylpropanoids) demonstrated concentration-dependent inhibitory or modulatory effects in a fibroblast cell culture model. The most potent inhibitory activity in this investigation was exhibited by apigenin (4), with flavone (1), chrysin (2), and genistein (9) being of somewhat lesser potency. These findings help to provide a better understanding of the action of these plant phenols in inflammatory/immune responses. ..more
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 Tested Compounds
 Tested Compounds
All(14)
 
 
Unspecified(14)
 
 
 Tested Substances
 Tested Substances
All(14)
 
 
Unspecified(14)
 
 
 Related BioAssays
 Related BioAssays
AID: 379089
Data Source: ChEMBL (527118)
BioAssay Type: Confirmatory, Concentration-Response Relationship Observed
Depositor Category: Literature, Extracted
BioAssay Version:
Deposit Date: 2010-05-26
Modify Date: 2014-05-25

Data Table ( Complete ):           View All Data
Tested Compounds:
Description:
Title: Activities of plant-derived phenols in a fibroblast cell culture model

Abstract: Fourteen plant phenols of five structural groups (flavones, flavonols, flavan-3-ol, isoflavones, and phenylpropanoids) demonstrated concentration-dependent inhibitory or modulatory effects in a fibroblast cell culture model. The most potent inhibitory activity in this investigation was exhibited by apigenin (4), with flavone (1), chrysin (2), and genistein (9) being of somewhat lesser potency. These findings help to provide a better understanding of the action of these plant phenols in inflammatory/immune responses.
(PMID: 10096863)
Comment
Putative Target:
ChEMBL Target ID: 22226
Target Type: UNCHECKED
Pref Name: Unchecked
Confidence: Default value - Target unknown or has yet to be assigned
Relationship Type: Default value - Target has yet to be curated
Categorized Comment - additional comments and annotations
From ChEMBL:
Assay Type: Functional
Assay Data Source: Scientific Literature
Result Definitions
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TIDNameDescriptionHistogramTypeUnit
OutcomeThe BioAssay activity outcomeOutcome
1IC50*IC50 PubChem standard valueFloatμM
2Activity activity commentActivity activity commentString
3Activity standard flagActivity standard flagInteger
4Activity qualifierActivity qualifierString
5Activity published valueActivity published valueFloat
6Activity standard valueActivity standard valueFloat
7Activity data validityActivity data validityString
8IC50 activity commentIC50 activity commentString
9IC50 standard flagIC50 standard flagInteger
10IC50 qualifierIC50 qualifierString
11IC50 published valueIC50 published valueFloatμM
12IC50 standard valueIC50 standard valueFloatnM
13IC50 data validityIC50 data validityString

* Activity Concentration.

Data Table (Concise)
Data Table ( Complete ):     View All Data
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