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BioAssay: AID 37275

Tested in vitro for the inhibition constant against human lysosomal alpha-glucosidase

Tested in vitro for the inhibition constant against human lysosomal alpha-glucosidase ..more
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 Tested Compounds
 Tested Compounds
All(5)
 
 
Active(5)
 
 
 Tested Substances
 Tested Substances
All(5)
 
 
Active(5)
 
 
 Related BioAssays
 Related BioAssays
AID: 37275
Data Source: ChEMBL (34405)
BioAssay Type: Confirmatory, Concentration-Response Relationship Observed
Depositor Category: Literature, Extracted
BioAssay Version:
Deposit Date: 2010-05-20
Modify Date: 2014-05-12

Data Table ( Complete ):           View Active Data    View All Data
BioActive Compounds: 5
Description:
Tested in vitro for the inhibition constant against human lysosomal alpha-glucosidase
Comment
Compounds with activity <= 50uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Putative Target:

ChEMBL Target ID: 10977
Target Type: SINGLE PROTEIN
Pref Name: Lysosomal alpha-glucosidase
Synonyms: 70 kDa lysosomal alpha-glucosidase;76 kDa lysosomal alpha-glucosidase;Acid maltase;Aglucosidase alfa;Lysosomal alpha-glucosidase;
Gene Name: GAA;
Protein Accession: P10253;
Protein GI: 317373572;
Organism: Homo sapiens
Tax ID: 9606
Target Classification: enzyme hydrolase
Confidence: Homologous single protein target assigned
Relationship Type: Homologous protein target assigned


Publication:
Journal: Bioorg. Med. Chem. Lett.
Year: 1997
Volume: 7
Issue: 3
First Page: 355
Last Page: 360
Categorized Comment
Assay Type: Binding

Assay Data Source: Scientific Literature

BAO: Assay Format: biochemical format

Result Definitions
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TIDNameDescriptionHistogramTypeUnit
OutcomeThe BioAssay activity outcomeOutcome
1Ki*Ki PubChem standard valueFloatμM
3BEIBinding Efficiency Index(nM)Float
2SEISurface Efficiency Index(nM)Float
4LELigand EfficiencyFloat
5LLELipophilic Ligand EfficiencyFloat
6Ki activity commentKi activity commentString
7Ki standard flagKi standard flagInteger
8Ki qualifierKi qualifierString
9Ki published valueKi published valueFloatμM
10Ki standard valueKi standard valueFloatnM

* Activity Concentration.

Data Table (Concise)
Data Table ( Complete ):     View Active Data    View All Data
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