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BioAssay: AID 363

Literature data for small-molecule inhibitors of Human Src.

This assay contains in vitro affinity data extracted from the literature for compounds tested against human Src protein. ..more
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 Tested Compounds
 Tested Compounds
All(749)
 
 
Active(725)
 
 
Inactive(24)
 
 
 Tested Substances
 Tested Substances
All(749)
 
 
Active(725)
 
 
Inactive(24)
 
 
 Related BioAssays
 Related BioAssays
AID: 363
Data Source: BindingDB (BindingDB_Human_Src)
Depositor Category: Literature, Extracted
BioAssay Version:
Deposit Date: 2006-01-31
Modify Date: 2010-06-30

Data Table ( Complete ):           View Active Data    View All Data
Target
BioActive Compounds: 725
Description:
This assay contains in vitro affinity data extracted from the literature for compounds tested against human Src protein.
Protocol
Various protocols were used; consult BindingDB and/or cited papers for details.
A compound is listed as "Active" if IC50<100,000 nanomolar or Ki<100,000 nanomolar.
If multiple measurements are available for a given compound, the compound is listed as "Active" if any of the measurements meet the criterion.
Comment
Publications sometimes list an IC50, say, as greater than or less than some cutoff value; e.g., "IC50 >5000 nanomolar".
IC50 is concentration of compound that yields 50% inhibition of the Src enzyme under the assay conditions.
Ki is the enzymologic inhibition constant.
Result Definitions
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TIDNameDescriptionAnnotationHistogramTypeUnit
OutcomeThe BioAssay activity outcomeOutcome
1Ki_maxThis field is used if either or both of two situations occur:

1) If a publication gives Ki as "<x"

2) If multiple Ki measurements are available for a compound, in which case Ki_max is the largest Ki of the set.
FloatnM
2KiThis field is used when a single Ki measurement is available for a compound and it is listed without a ">" or "<" symbol.FloatnM
3Ki_minThis field is used if either or both of two situations occur:

1) If a publication gives Ki as ">x"

2) If multiple Ki measurements are available for a compound, in which case Ki_min is the smallest Ki of the set.
FloatnM
4IC50_maxThis field is used if either or both of two situations occur:

1) If a publication gives IC50 as "<x"

2) If multiple IC50 measurements are available for a compound, in which case IC50_max is the largest IC50 of the set.
FloatnM
5IC50This field is used when a single IC50 measurement is available for a compound and it is listed without a ">" or "<" symbol.FloatnM
6IC50_minThis field is used if either or both of two situations occur:

1) If a publication gives IC50 as ">x"

2) If multiple IC50 measurements are available for a compound, in which case IC50_min is the smallest IC50 of the set.
FloatnM
7BindingDB Target NameBrief name of the assay target as used in BindingDB.String
8BindingDB Target Other NamesAlternative name(s) of the assay target listed in BindingDB.String
9PubMedPubMed ID(s) for paper(s) from which data were extracted. If multiple IDs, they are separated by commas.PMIDString

Data Table (Concise)
Data Table ( Complete ):     View Active Data    View All Data
Classification
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