Agonist activity at NR2E3 by beta lactamase transactivation assay - BioAssay Summary
Agonists of NR2E3 (PNR, RNR) have been identified and optimized to EC(50)< 200 nM. A tritiated analogue of one agonist was prepared to aid in the development of a binding assay. ..more
 _
   
 Tested Compounds
 Tested Compounds
All(18)
 
 
Active(14)
 
 
Unspecified(4)
 
 
 Tested Substances
 Tested Substances
All(18)
 
 
Active(14)
 
 
Unspecified(4)
 
 
 Related BioAssays
 Related BioAssays
Table of Contents
AID: 271158
Data Source: ChEMBL (401901)
Depositor Category: Literature, Extracted
BioAssay Version:
Deposit Date: 2010-05-25
Modify Date: 2013-05-05

Data Table (Complete):           Active    All
Target
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Sequence: RecName: Full=Photoreceptor-specific nuclear receptor; AltName: Full=Nuclear receptor subfamily 2 group E member 3; AltName: Full=Retina-specific nuclear receptor
Description ..   
Protein Family: The ligand binding domain of Tailless-like proteins, orphan nuclear receptors
Comment ..   

Gene:NR2E3     Related Protein 3D Structures
BioActive Compounds: 14
Description:
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Title: Identification of potent agonists of photoreceptor-specific nuclear receptor (NR2E3) and preparation of a radioligand.

Abstract: Agonists of NR2E3 (PNR, RNR) have been identified and optimized to EC(50)< 200 nM. A tritiated analogue of one agonist was prepared to aid in the development of a binding assay.
(PMID: 16879962)
Comment
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Compounds with activity <= 50uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Categorized Comment
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ChEMBL Assay Type: Functional

ChEMBL Assay Data Source: Scientific Literature

ChEMBL Target ID: 100788

ChEMBL target type: Target is a single protein chain

Result Definitions
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TIDNameDescriptionHistogramTypeUnit
OutcomeThe BioAssay activity outcomeOutcome
1EC50*EC50 PubChem standard valueFloatμM
2EC50 activity commentEC50 activity commentString
3EC50 standard flagEC50 standard flagInteger
4EC50 qualifierEC50 qualifierString
5EC50 published valueEC50 published valueFloatnM
6EC50 standard valueEC50 standard valueFloatnM
* Activity Concentration.

Data Table (Concise)
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Classification
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