A series of structurally novel aminothiazole based small molecule inhibitors of Itk were prepared to elucidate their structure-activity relationships (SARs), selectivity, and cell activity in inhibiting IL-2 secretion in a Jurkat T-cell assay. Compound 3 is identified as a potent and selective Itk inhibitor which inhibits anti-TCR antibody induced IL-2 production in mice in vivo and was previously reported to reduce lung inflammation in a mouse model of ovalbumin induced allergy/asthma. ..more
Tested Compound:
Description:
Title: Discovery and SAR of 2-amino-5-(thioaryl)thiazoles as potent and selective Itk inhibitors.
Abstract: A series of structurally novel aminothiazole based small molecule inhibitors of Itk were prepared to elucidate their structure-activity relationships (SARs), selectivity, and cell activity in inhibiting IL-2 secretion in a Jurkat T-cell assay. Compound 3 is identified as a potent and selective Itk inhibitor which inhibits anti-TCR antibody induced IL-2 production in mice in vivo and was previously reported to reduce lung inflammation in a mouse model of ovalbumin induced allergy/asthma.
(PMID: 16682193)
Abstract: A series of structurally novel aminothiazole based small molecule inhibitors of Itk were prepared to elucidate their structure-activity relationships (SARs), selectivity, and cell activity in inhibiting IL-2 secretion in a Jurkat T-cell assay. Compound 3 is identified as a potent and selective Itk inhibitor which inhibits anti-TCR antibody induced IL-2 production in mice in vivo and was previously reported to reduce lung inflammation in a mouse model of ovalbumin induced allergy/asthma.
(PMID: 16682193)
Comment
Putative Target:
ChEMBL Target ID: 22226
Target Type: UNCHECKED
Pref Name: Unchecked
Confidence: Multiple direct protein targets may be assigned
Relationship Type: Direct protein target assigned
ChEMBL Target ID: 22226
Target Type: UNCHECKED
Pref Name: Unchecked
Confidence: Multiple direct protein targets may be assigned
Relationship Type: Direct protein target assigned
Categorized Comment
ChEMBL Assay Type: Binding
ChEMBL Assay Data Source: Scientific Literature
ChEMBL Target ID: 22226
ChEMBL target type: NULL
ChEMBL Assay Data Source: Scientific Literature
ChEMBL Target ID: 22226
ChEMBL target type: NULL
Result Definitions
| TID | Name | Description | Histogram | Type | Unit | |
|---|---|---|---|---|---|---|
| Outcome | The BioAssay activity outcome | Outcome | ||||
| 1 | Selectivity ratio activity comment | Selectivity ratio activity comment | String | |||
| 2 | Selectivity ratio standard flag | Selectivity ratio standard flag |  | Integer | ||
| 3 | Selectivity ratio qualifier | Selectivity ratio qualifier | String | |||
| 4 | Selectivity ratio published value | Selectivity ratio published value | | Float | ||
| 5 | Selectivity ratio standard value | Selectivity ratio standard value | | Float |
Data Table (Concise)
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