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BioAssay: AID 25611

Dissociation constant (pKa)

Phenols and fatty acids were found to inhibit L-alanine-initiated germination of Bacillus subtilis spores without altering their heat resistance. Inhibitory effect was defined as the concentration necessary to cause 50% inhibition of the germination rate. The quantitative structure-inhibitory activity relationships for 39 phenols and 7 fatty acids were analyzed. The pH dependency of inhibition more ..
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 Tested Compounds
 Tested Compounds
All(48)
 
 
Unspecified(48)
 
 
 Tested Substances
 Tested Substances
All(48)
 
 
Unspecified(48)
 
 
 Related BioAssays
 Related BioAssays
AID: 25611
Data Source: ChEMBL (22732)
Depositor Category: Literature, Extracted
BioAssay Version:
Deposit Date: 2010-05-21
Modify Date: 2014-05-19

Data Table ( Complete ):           All
Tested Compounds:
Description:
Title: Quantitative structure-inhibitory activity relationships of phenols and fatty acids for Bacillus subtilis spore germination.

Abstract: Phenols and fatty acids were found to inhibit L-alanine-initiated germination of Bacillus subtilis spores without altering their heat resistance. Inhibitory effect was defined as the concentration necessary to cause 50% inhibition of the germination rate. The quantitative structure-inhibitory activity relationships for 39 phenols and 7 fatty acids were analyzed. The pH dependency of inhibition showed that the nonionized form of the molecule was responsible for inhibition. Hydrophobicity, which was expressed by the partition coefficient or the distribution coefficient of the compounds, was important for inhibition. In addition to hydrophobicity, the electronic effect, which was expressed by the dissociation constant, played a partial role in phenols. The correlation equation of the fatty acids was similar to those of the alcohols and other hydrophobic compounds, which had been reported earlier. That of the phenols, however, appeared to be different, indicating a different and more complex mechanism of inhibition. The type of inhibition by both compounds was mixed rather than competitive or noncompetitive.
(PMID: 6802973)
Comment
Putative Target:

ChEMBL Target ID: 22229
Target Type: NO TARGET
Pref Name: No relevant target
Confidence: Default value - Target unknown or has yet to be assigned
Relationship Type: Default value - Target has yet to be curated
Categorized Comment
Assay Type: Physicochemical

Assay Data Source: Scientific Literature

BAO: Assay Format: small-molecule physicochemical format

Result Definitions
TIDNameDescriptionHistogramTypeUnit
OutcomeThe BioAssay activity outcomeOutcome
1pKa activity commentpKa activity commentString
2pKa standard flagpKa standard flagInteger
3pKa qualifierpKa qualifierString
4pKa published valuepKa published valueFloat
5pKa standard valuepKa standard valueFloat

Data Table (Concise)
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