Bookmark and Share
BioAssay: AID 244222

Ratio of binding affinity for mouse brain Gamma-aminobutyric acid receptor and housefly Gamma-aminobutyric acid receptor

A convenient synthetic route to novel 4-arylpyrazoles is described. The potential for insecticidal activity through GABA channel blockage by this series of compounds, as well as their selectivity for insect versus mammalian receptors, are explored through in vitro and in vivo assays. ..more
_
   
 Tested Compounds
 Tested Compounds
All(30)
 
 
Unspecified(30)
 
 
 Tested Substances
 Tested Substances
All(30)
 
 
Unspecified(30)
 
 
 Related BioAssays
 Related BioAssays
AID: 244222
Data Source: ChEMBL (308316)
Depositor Category: Literature, Extracted
BioAssay Version:
Deposit Date: 2010-05-24
Modify Date: 2014-05-20

Data Table ( Complete ):           View All Data
Targets
Sequence: RecName: Full=Gamma-aminobutyric acid receptor subunit alpha-2; AltName: Full=GABA(A) receptor subunit alpha-2; Flags: Precursor
Description ..   
Protein Family: Neurotransmitter-gated ion-channel ligand binding domain
Comment ..   

Gene:GABRA2     Related Protein 3D Structures     More BioActivity Data..


more...  
Tested Compounds:
Description:
Title: Synthesis and GABA receptor potency of 3-thiomethyl-4-(hetero)aryl-5-amino-1-phenylpyrazoles.

Abstract: A convenient synthetic route to novel 4-arylpyrazoles is described. The potential for insecticidal activity through GABA channel blockage by this series of compounds, as well as their selectivity for insect versus mammalian receptors, are explored through in vitro and in vivo assays.
(PMID: 15341958)
Categorized Comment
Assay Type: Binding

Assay Data Source: Scientific Literature

Result Definitions
TIDNameDescriptionHistogramTypeUnit
OutcomeThe BioAssay activity outcomeOutcome
1Selectivity activity commentSelectivity activity commentString
2Selectivity standard flagSelectivity standard flagInteger
3Selectivity qualifierSelectivity qualifierString
4Selectivity published valueSelectivity published valueFloat
5Selectivity standard valueSelectivity standard valueFloat

Data Table (Concise)
Data Table ( Complete ):     View All Data
Classification
PageFrom: