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BioAssay: AID 234937

Relative affinity for rat vasopressin receptors V1a and V2

Title: 5-Fluoro-2-methyl-N-[4-(5H-pyrrolo[2,1-c]-[1, 4]benzodiazepin-10(11H)-ylcarbonyl)-3-chlorophenyl]benzamide (VPA-985): an orally active arginine vasopressin antagonist with selectivity for V2 receptors.
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 Tested Compounds
 Tested Compounds
All(12)
 
 
Unspecified(12)
 
 
 Tested Substances
 Tested Substances
All(12)
 
 
Unspecified(12)
 
 
 Related BioAssays
 Related BioAssays
AID: 234937
Data Source: ChEMBL (232294)
Depositor Category: Literature, Extracted
BioAssay Version:
Deposit Date: 2010-05-24
Modify Date: 2014-08-24

Data Table ( Complete ):           View All Data
Targets
Sequence: RecName: Full=Vasopressin V2 receptor; Short=V2R; AltName: Full=AVPR V2; AltName: Full=Antidiuretic hormone receptor; AltName: Full=Renal-type arginine vasopressin receptor
Description ..   
Comment ..   

Gene:AVPR2     Conserved Domain     Related Protein 3D Structures     More BioActivity Data..

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Tested Compounds:
Description:
Title: 5-Fluoro-2-methyl-N-[4-(5H-pyrrolo[2,1-c]-[1, 4]benzodiazepin-10(11H)-ylcarbonyl)-3-chlorophenyl]benzamide (VPA-985): an orally active arginine vasopressin antagonist with selectivity for V2 receptors.
(PMID: 9651149)
Categorized Comment - additional comments and annotations
From BioAssay Depositor:
Assay Type: Binding
Target Type: Target is a group of closely related proteins
Assay Data Source: Scientific Literature
Result Definitions
TIDNameDescriptionHistogramTypeUnit
OutcomeThe BioAssay activity outcomeOutcome
1Selectivity activity commentSelectivity activity commentString
2Selectivity standard flagSelectivity standard flagInteger
3Selectivity qualifierSelectivity qualifierString
4Selectivity published valueSelectivity published valueFloat
5Selectivity standard valueSelectivity standard valueFloat

Data Table (Concise)
Data Table ( Complete ):     View All Data
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