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BioAssay: AID 228484

NO-releasing ability under the oxidation by horseradish peroxidase (HRP) in the presence of H2O2 for 20min, expressed as nitrite concentration

The electrochemical properties of a series of N-substituted-N'-hydroxyguanidines were studied. Two oxidation potentials of each compound were obtained by cyclic voltammetry. The E(ox1) values were from 0.51 to 0.62V, while the E(ox2) values were from 1.14 to 1.81V in acetonitrile solution. Next, their enzymatic controlled NO release abilities were evaluated. All N'-hydroxyguanidines exhibited efficient NO release abilities under the oxidation by horseradish peroxidase in the presence of H(2)O(2). ..more
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 Tested Compounds
 Tested Compounds
All(12)
 
 
Active(6)
 
 
Unspecified(6)
 
 
 Tested Substances
 Tested Substances
All(12)
 
 
Active(6)
 
 
Unspecified(6)
 
 
 Related BioAssays
 Related BioAssays
AID: 228484
Data Source: ChEMBL (225841)
Depositor Category: Literature, Extracted
BioAssay Version:
Deposit Date: 2010-05-20
Modify Date: 2014-05-19

Data Table ( Complete ):           View Active Data    View All Data
BioActive Compounds: 6
Description:
Title: Electrochemical and peroxidase oxidation study of N'-hydroxyguanidine derivatives as NO donors.

Abstract: The electrochemical properties of a series of N-substituted-N'-hydroxyguanidines were studied. Two oxidation potentials of each compound were obtained by cyclic voltammetry. The E(ox1) values were from 0.51 to 0.62V, while the E(ox2) values were from 1.14 to 1.81V in acetonitrile solution. Next, their enzymatic controlled NO release abilities were evaluated. All N'-hydroxyguanidines exhibited efficient NO release abilities under the oxidation by horseradish peroxidase in the presence of H(2)O(2).
(PMID: 12031330)
Comment
Compounds with activity <= 50uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Putative Target:

ChEMBL Target ID: 22226
Target Type: UNCHECKED
Pref Name: Unchecked
Confidence: Default value - Target unknown or has yet to be assigned
Relationship Type: Default value - Target has yet to be curated
Categorized Comment
Assay Type: Functional

Assay Data Source: Scientific Literature

Result Definitions
TIDNameDescriptionHistogramTypeUnit
OutcomeThe BioAssay activity outcomeOutcome
1Concentration activity commentConcentration activity commentString
2Concentration standard flagConcentration standard flagInteger
3Concentration qualifierConcentration qualifierString
4Concentration published valueConcentration published valueFloatμM
5Concentration standard valueConcentration standard valueFloatnM

Data Table (Concise)
Data Table ( Complete ):     View Active Data    View All Data
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