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BioAssay: AID 224294

Dissociation constant for binding to SH2 domain of p56 lck tyrosine kinase

Title: Acquisition of high-affinity, SH2-targeted ligands via a spatially focused library.
 Tested Compounds
 Tested Compounds
 Tested Substances
 Tested Substances
 Related BioAssays
 Related BioAssays
AID: 224294
Data Source: ChEMBL (221648)
BioAssay Type: Confirmatory, Concentration-Response Relationship Observed
Depositor Category: Literature, Extracted
BioAssay Version:
Deposit Date: 2010-05-24
Modify Date: 2014-08-23

Data Table ( Complete ):           View Active Data    View All Data
BioActive Compounds: 7
Title: Acquisition of high-affinity, SH2-targeted ligands via a spatially focused library.
(PMID: 10072676)
Compounds with activity <= 50uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Putative Target:

ChEMBL Target ID: 10140
Pref Name: Tyrosine-protein kinase LCK
Synonyms: Leukocyte C-terminal Src kinase;LSK;Lymphocyte cell-specific protein-tyrosine kinase;p56-LCK;Protein YT16;Proto-oncogene Lck;T cell-specific protein-tyrosine kinase;Tyrosine-protein kinase Lck;
Gene Name: LCK;
Protein Accession: P06239;
Protein GI: 125474;
Organism: Homo sapiens
Tax ID: 9606
Target Classification: enzyme kinase protein kinase tk src
Confidence: Homologous single protein target assigned
Relationship Type: Homologous protein target assigned
Categorized Comment - additional comments and annotations
From BioAssay Depositor:
Assay Type: Binding
Assay Data Source: Scientific Literature
Result Definitions
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OutcomeThe BioAssay activity outcomeOutcome
1Kd*Kd PubChem standard valueFloatμM
3BEIBinding Efficiency Index(nM)Float
2SEISurface Efficiency Index(nM)Float
4LELigand EfficiencyFloat
5LLELipophilic Ligand EfficiencyFloat
6Kd activity commentKd activity commentString
7Kd standard flagKd standard flagInteger
8Kd qualifierKd qualifierString
9Kd published valueKd published valueFloatnM
10Kd standard valueKd standard valueFloatnM

* Activity Concentration.

Data Table (Concise)
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