The Renal Outer Medullary Potassium channel (ROMK, Kir1.1) is expressed in the renal tubule where it critically regulates fluid and electrolyte homeostasis (1). An emerging body of evidence suggests that ROMK could be a target for a novel class loop diuretic that lowers blood pressure while preserving plasma potassium levels (2). Furthermore, homozygous loss-of-function mutations in the gene more ..
BioActive Compound: 1
Depositor Specified Assays
| AID | Name | Type | Comment |
|---|---|---|---|
| 2436 | High-throughput Discovery of Novel Modulators of ROMK K+ Channel Activity | summary |
Description:
Assay Provider: Jerod Denton
Assay Provider Affiliation: Vanderbilt University
Grant Title: High throughput discovery of novel modulators of ROMK K+ channel activity
Grant Number: R21 NS057041-01
The Renal Outer Medullary Potassium channel (ROMK, Kir1.1) is expressed in the renal tubule where it critically regulates fluid and electrolyte homeostasis (1). An emerging body of evidence suggests that ROMK could be a target for a novel class loop diuretic that lowers blood pressure while preserving plasma potassium levels (2). Furthermore, homozygous loss-of-function mutations in the gene encoding ROMK (KCNJ1) cause antenatal Bartter syndrome, a severe salt and water wasting disease in infants (3). ROMK is thus an important pharmacological target for the management of disease. Its actual therapeutic value and drugability, however, are unknown due to the lack of small-molecule probes targeting the channel. The discovery of ROMK modulators will provide important new tools for studying the structure, function and therapeutic potential of ROMK and other inward rectifying potassium channels.
1.Hebert SC, Desir G, Giebisch G, Wang W. Molecular diversity and regulation of renal potassium channels. Physiol Rev. 2005;85(1):319-371.
2.Ji W, Foo JN, O'Roak BJ, Zhao H, Larson MG, Simon DB, Newton-Cheh C, State MW, Levy D, Lifton RP. Rare independent mutations in renal salt handling genes contribute to blood pressure variation. Nat Genet. 2008;40(5):592-599.
3.Simon DB, Karet FE, Rodriguez-Soriano J, Hamdan JH, DiPietro A, Trachtman H, Sanjad SA, Lifton RP. Genetic heterogeneity of Bartter's syndrome revealed by mutations in the K+ channel, ROMK. Nat Genet. 1996;14(2):152-156.
Assay Provider Affiliation: Vanderbilt University
Grant Title: High throughput discovery of novel modulators of ROMK K+ channel activity
Grant Number: R21 NS057041-01
The Renal Outer Medullary Potassium channel (ROMK, Kir1.1) is expressed in the renal tubule where it critically regulates fluid and electrolyte homeostasis (1). An emerging body of evidence suggests that ROMK could be a target for a novel class loop diuretic that lowers blood pressure while preserving plasma potassium levels (2). Furthermore, homozygous loss-of-function mutations in the gene encoding ROMK (KCNJ1) cause antenatal Bartter syndrome, a severe salt and water wasting disease in infants (3). ROMK is thus an important pharmacological target for the management of disease. Its actual therapeutic value and drugability, however, are unknown due to the lack of small-molecule probes targeting the channel. The discovery of ROMK modulators will provide important new tools for studying the structure, function and therapeutic potential of ROMK and other inward rectifying potassium channels.
1.Hebert SC, Desir G, Giebisch G, Wang W. Molecular diversity and regulation of renal potassium channels. Physiol Rev. 2005;85(1):319-371.
2.Ji W, Foo JN, O'Roak BJ, Zhao H, Larson MG, Simon DB, Newton-Cheh C, State MW, Levy D, Lifton RP. Rare independent mutations in renal salt handling genes contribute to blood pressure variation. Nat Genet. 2008;40(5):592-599.
3.Simon DB, Karet FE, Rodriguez-Soriano J, Hamdan JH, DiPietro A, Trachtman H, Sanjad SA, Lifton RP. Genetic heterogeneity of Bartter's syndrome revealed by mutations in the K+ channel, ROMK. Nat Genet. 1996;14(2):152-156.
Protocol
The purpose of this assay was to test the lead compound against a broad panel of targets to determine ancillary activity.
MDS Pharma (The Triad, 2200 Renaissance Blvd, Suite 400, King of Prussia, PA 19406-2755) performed a Lead Profiling Screen of GPCRs, ion channels and transporters against the compound at 10uM concentration. The compound inhibited 4 targets: Dopamine D4, GABAa, DAT and NET. Upon obtaining full CRCs for these four off-target activiites, only GABAa afforded and IC50 < 10uM (GABAa IC50 = 6.2 uM)allowing for 28-fold selectivity for ROMK. Notably, it was inactive on hERG and both L- and N- type calcium channels in this panel.
MDS Pharma (The Triad, 2200 Renaissance Blvd, Suite 400, King of Prussia, PA 19406-2755) performed a Lead Profiling Screen of GPCRs, ion channels and transporters against the compound at 10uM concentration. The compound inhibited 4 targets: Dopamine D4, GABAa, DAT and NET. Upon obtaining full CRCs for these four off-target activiites, only GABAa afforded and IC50 < 10uM (GABAa IC50 = 6.2 uM)allowing for 28-fold selectivity for ROMK. Notably, it was inactive on hERG and both L- and N- type calcium channels in this panel.
Result Definitions
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| TID | Name | Description | Annotation | Histogram | Type | Unit |
|---|---|---|---|---|---|---|
| Outcome | The BioAssay activity outcome | Outcome | ||||
| Score | The BioAssay activity ranking score |  | Integer | |||
| 1 | Adenosine A1 (human) (10μM**) | % Inhibition at Adenosine A1 (human) as reported by MDS | | Integer | % | |
| 2 | Adenosine A1 (human) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 3 | Adenosine A1 (human) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 4 | Adenosine A1 (human) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 5 | Adenosine A2 (human) (10μM**) | % Inhibition at Adenosine A2 (human) as reported by MDS | | Integer | % | |
| 6 | Adenosine A2 (human) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 7 | Adenosine A2 (human) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 8 | Adenosine A2 (human) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 9 | Adenosine A3 (human) (10μM**) | % Inhibition at Adenosine A3 (human) as reported by MDS | | Integer | % | |
| 10 | Adenosine A3 (human) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 11 | Adenosine A3 (human) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 12 | Adenosine A3 (human) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 13 | Adrenergic a1A (rat) (10μM**) | % Inhibition at Adrenergic a1A (rat) as reported by MDS | | Integer | % | |
| 14 | Adrenergic a1A (rat) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 15 | Adrenergic a1A (rat) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 16 | Adrenergic a1A (rat) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 17 | Adrenergic a1B (rat) (10μM**) | % Inhibition at Adrenergic a1B (rat) as reported by MDS | | Integer | % | |
| 18 | Adrenergic a1B (rat) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 19 | Adrenergic a1B (rat) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 20 | Adrenergic a1B (rat) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 21 | Adrenergic a1D (human) (10μM**) | % Inhibition at Adrenergic a1D (human) as reported by MDS | | Integer | % | |
| 22 | Adrenergic a1D (human) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 23 | Adrenergic a1D (human) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 24 | Adrenergic a1D (human) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 25 | Adrenergic a2A (human) (10μM**) | % Inhibition at Adrenergic a2A (human) as reported by MDS | | Integer | % | |
| 26 | Adrenergic a2A (human) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 27 | Adrenergic a2A (human) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 28 | Adrenergic a2A (human) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 29 | Adrenergic b1 (human) (10μM**) | % Inhibition at Adrenergic b1 (human) as reported by MDS | | Integer | % | |
| 30 | Adrenergic b1 (human) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 31 | Adrenergic b1 (human) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 32 | Adrenergic b1 (human) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 33 | Adrenergic b2 (human) (10μM**) | % Inhibition at Adrenergic b2 (human) as reported by MDS | | Integer | % | |
| 34 | Adrenergic b2 (human) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 35 | Adrenergic b2 (human) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 36 | Adrenergic b2 (human) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 37 | Androgen (testosterone)AR (rat) (10μM**) | % Inhibition at Androgen (testosterone)AR (rat) as reported by MDS | | Integer | % | |
| 38 | Androgen (testosterone)AR (rat) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 39 | Androgen (testosterone)AR (rat) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 40 | Androgen (testosterone)AR (rat) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 41 | Bradykinin B1 (human) (10μM**) | % Inhibition at Bradykinin B1 (human) as reported by MDS | | Integer | % | |
| 42 | Bradykinin B1 (human) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 43 | Bradykinin B1 (human) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 44 | Bradykinin B1 (human) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 45 | Bradykinin B2 (human) (10μM**) | % Inhibition at Bradykinin B2 (human) as reported by MDS | | Integer | % | |
| 46 | Bradykinin B2 (human) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 47 | Bradykinin B2 (human) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 48 | Bradykinin B2 (human) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 49 | Calcium channel L -type, benzothiazepine (rat) (10μM**) | % Inhibition at Calcium channel L -type, benzothiazepine (rat) as reported by MDS | | Integer | % | |
| 50 | Calcium channel L -type, benzothiazepine (rat) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 51 | Calcium channel L -type, benzothiazepine (rat) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 52 | Calcium channel L -type, benzothiazepine (rat) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 53 | Calcium channel L -type, dihydropyridine (rat) (10μM**) | % Inhibition at Calcium channel L -type, dihydropyridine (rat) as reported by MDS | | Integer | % | |
| 54 | Calcium channel L -type, dihydropyridine (rat) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 55 | Calcium channel L -type, dihydropyridine (rat) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 56 | Calcium channel L -type, dihydropyridine (rat) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 57 | Calcium channel N-type (rat) (10μM**) | % Inhibition at Calcium channel N-type (rat) as reported by MDS | | Integer | % | |
| 58 | Calcium channel N-type (rat) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 59 | Calcium channel N-type (rat) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 60 | Calcium channel N-type (rat) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 61 | Dopamine D 1 (human) (10μM**) | % Inhibition at Dopamine D 1 (human) as reported by MDS | | Integer | % | |
| 62 | Dopamine D 1 (human) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 63 | Dopamine D 1 (human) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 64 | Dopamine D 1 (human) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 65 | Dopamine D 2S (human) (10μM**) | % Inhibition at Dopamine D 2S (human) as reported by MDS | | Integer | % | |
| 66 | Dopamine D 2S (human) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 67 | Dopamine D 2S (human) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 68 | Dopamine D 2S (human) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 69 | Dopamine D 4.2 (human) (10μM**) | % Inhibition at Dopamine D 4.2 (human) as reported by MDS | | Integer | % | |
| 70 | Dopamine D 4.2 (human) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 71 | Dopamine D 4.2 (human) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 72 | Dopamine D 4.2 (human) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 73 | Dopamine D3 (human) (10μM**) | % Inhibition at Dopamine D3 (human) as reported by MDS | | Integer | % | |
| 74 | Dopamine D3 (human) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 75 | Dopamine D3 (human) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 76 | Dopamine D3 (human) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 77 | Endothelin ETA (human) (10μM**) | % Inhibition at Endothelin ETA (human) as reported by MDS | | Integer | % | |
| 78 | Endothelin ETA (human) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 79 | Endothelin ETA (human) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 80 | Endothelin ETA (human) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 81 | Endothelin ETB (human) (10μM**) | % Inhibition at Endothelin ETB (human) as reported by MDS | | Integer | % | |
| 82 | Endothelin ETB (human) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 83 | Endothelin ETB (human) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 84 | Endothelin ETB (human) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 85 | Epidermal Growth Factor (EGF) (human) (10μM**) | % Inhibition at Epidermal Growth Factor (EGF) (human) as reported by MDS | | Integer | % | |
| 86 | Epidermal Growth Factor (EGF) (human) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 87 | Epidermal Growth Factor (EGF) (human) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 88 | Epidermal Growth Factor (EGF) (human) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 89 | Estrogen ER a (human) (10μM**) | % Inhibition at Estrogen ER a (human) as reported by MDS | | Integer | % | |
| 90 | Estrogen ER a (human) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 91 | Estrogen ER a (human) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 92 | Estrogen ER a (human) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 93 | G protein-coupled receptor GPR103 (human) (10μM**) | % Inhibition at G protein-coupled receptor GPR103 (human) as reported by MDS | | Integer | % | |
| 94 | G protein-coupled receptor GPR103 (human) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 95 | G protein-coupled receptor GPR103 (human) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 96 | G protein-coupled receptor GPR103 (human) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 97 | GABA B1A (human) (10μM**) | % Inhibition at GABA B1A (human) as reported by MDS | | Integer | % | |
| 98 | GABA B1A (human) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 99 | GABA B1A (human) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 100 | GABA B1A (human) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 101 | GABAAFlunitrazepam, central (rat) (10μM**) | % Inhibition at GABAAFlunitrazepam, central (rat) as reported by MDS | | Integer | % | |
| 102 | GABAAFlunitrazepam, central (rat) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 103 | GABAAFlunitrazepam, central (rat) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 104 | GABAAFlunitrazepam, central (rat) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 105 | GABAAMuscimol, central (rat) (10μM**) | % Inhibition at GABAAMuscimol, central (rat) as reported by MDS | | Integer | % | |
| 106 | GABAAMuscimol, central (rat) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 107 | GABAAMuscimol, central (rat) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 108 | GABAAMuscimol, central (rat) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 109 | Glucocorticoid (human) (10μM**) | % Inhibition at Glucocorticoid (human) as reported by MDS | | Integer | % | |
| 110 | Glucocorticoid (human) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 111 | Glucocorticoid (human) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 112 | Glucocorticoid (human) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 113 | Glutamate, Kainate (rat) (10μM**) | % Inhibition at Glutamate, Kainate (rat) as reported by MDS | | Integer | % | |
| 114 | Glutamate, Kainate (rat) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 115 | Glutamate, Kainate (rat) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 116 | Glutamate, Kainate (rat) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 117 | Glutamate, NMDA, Agonism (rat) (10μM**) | % Inhibition at Glutamate, NMDA, Agonism (rat) as reported by MDS | | Integer | % | |
| 118 | Glutamate, NMDA, Agonism (rat) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 119 | Glutamate, NMDA, Agonism (rat) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 120 | Glutamate, NMDA, Agonism (rat) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 121 | Glutamate, NMDA, Glycine (rat) (10μM**) | % Inhibition at Glutamate, NMDA, Glycine (rat) as reported by MDS | | Integer | % | |
| 122 | Glutamate, NMDA, Glycine (rat) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 123 | Glutamate, NMDA, Glycine (rat) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 124 | Glutamate, NMDA, Glycine (rat) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 125 | Glutamate, NMDA, Phencyclidine (rat) (10μM**) | % Inhibition at Glutamate, NMDA, Phencyclidine (rat) as reported by MDS | | Integer | % | |
| 126 | Glutamate, NMDA, Phencyclidine (rat) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 127 | Glutamate, NMDA, Phencyclidine (rat) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 128 | Glutamate, NMDA, Phencyclidine (rat) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 129 | Histamine H1 (human) (10μM**) | % Inhibition at Histamine H1 (human) as reported by MDS | | Integer | % | |
| 130 | Histamine H1 (human) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 131 | Histamine H1 (human) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 132 | Histamine H1 (human) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 133 | Histamine H2 (human) (10μM**) | % Inhibition at Histamine H2 (human) as reported by MDS | | Integer | % | |
| 134 | Histamine H2 (human) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 135 | Histamine H2 (human) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 136 | Histamine H2 (human) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 137 | Histamine H3 (human) (10μM**) | % Inhibition at Histamine H3 (human) as reported by MDS | | Integer | % | |
| 138 | Histamine H3 (human) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 139 | Histamine H3 (human) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 140 | Histamine H3 (human) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 141 | Imidazoline I2, central (rat) (10μM**) | % Inhibition at Imidazoline I2, central (rat) as reported by MDS | | Integer | % | |
| 142 | Imidazoline I2, central (rat) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 143 | Imidazoline I2, central (rat) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 144 | Imidazoline I2, central (rat) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 145 | Interleukin IL-1 (mouse) (10μM**) | % Inhibition at Interleukin IL-1 (mouse) as reported by MDS | | Integer | % | |
| 146 | Interleukin IL-1 (mouse) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 147 | Interleukin IL-1 (mouse) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 148 | Interleukin IL-1 (mouse) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 149 | Leukotriene, Cysteinyl CysLT1 (human) (10μM**) | % Inhibition at Leukotriene, Cysteinyl CysLT1 (human) as reported by MDS | | Integer | % | |
| 150 | Leukotriene, Cysteinyl CysLT1 (human) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 151 | Leukotriene, Cysteinyl CysLT1 (human) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 152 | Leukotriene, Cysteinyl CysLT1 (human) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 153 | Melatonin MT1 (human) (10μM**) | % Inhibition at Melatonin MT1 (human) as reported by MDS | | Integer | % | |
| 154 | Melatonin MT1 (human) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 155 | Melatonin MT1 (human) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 156 | Melatonin MT1 (human) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 157 | Muscarinic M1 (human) (10μM**) | % Inhibition at Muscarinic M1 (human) as reported by MDS | | Integer | % | |
| 158 | Muscarinic M1 (human) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 159 | Muscarinic M1 (human) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 160 | Muscarinic M1 (human) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 161 | Muscarinic M2 (human) (10μM**) | % Inhibition at Muscarinic M2 (human) as reported by MDS | | Integer | % | |
| 162 | Muscarinic M2 (human) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 163 | Muscarinic M2 (human) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 164 | Muscarinic M2 (human) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 165 | Muscarinic M3 (human) (10μM**) | % Inhibition at Muscarinic M3 (human) as reported by MDS | | Integer | % | |
| 166 | Muscarinic M3 (human) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 167 | Muscarinic M3 (human) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 168 | Muscarinic M3 (human) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 169 | Neuropeptide Y Y1 (human) (10μM**) | % Inhibition at Neuropeptide Y Y1 (human) as reported by MDS | | Integer | % | |
| 170 | Neuropeptide Y Y1 (human) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 171 | Neuropeptide Y Y1 (human) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 172 | Neuropeptide Y Y1 (human) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 173 | Neuropeptide Y Y2 (human) (10μM**) | % Inhibition at Neuropeptide Y Y2 (human) as reported by MDS | | Integer | % | |
| 174 | Neuropeptide Y Y2 (human) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 175 | Neuropeptide Y Y2 (human) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 176 | Neuropeptide Y Y2 (human) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 177 | Nicotinic Acetylcholine (human) (10μM**) | % Inhibition at Nicotinic Acetylcholine (human) as reported by MDS | | Integer | % | |
| 178 | Nicotinic Acetylcholine (human) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 179 | Nicotinic Acetylcholine (human) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 180 | Nicotinic Acetylcholine (human) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 181 | Nicotinic Acetylcholine 1 a , Bungarotoxin (human) (10μM**) | % Inhibition at Nicotinic Acetylcholine 1 a , Bungarotoxin (human) as reported by MDS | | Integer | % | |
| 182 | Nicotinic Acetylcholine 1 a , Bungarotoxin (human) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 183 | Nicotinic Acetylcholine 1 a , Bungarotoxin (human) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 184 | Nicotinic Acetylcholine 1 a , Bungarotoxin (human) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 185 | Opiate d (OP1, DOP) (human) (10μM**) | % Inhibition at Opiate d (OP1, DOP) (human) as reported by MDS | | Integer | % | |
| 186 | Opiate d (OP1, DOP) (human) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 187 | Opiate d (OP1, DOP) (human) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 188 | Opiate d (OP1, DOP) (human) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 189 | Opiate k (OP2, KOP) (human) (10μM**) | % Inhibition at Opiate k (OP2, KOP) (human) as reported by MDS | | Integer | % | |
| 190 | Opiate k (OP2, KOP) (human) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 191 | Opiate k (OP2, KOP) (human) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 192 | Opiate k (OP2, KOP) (human) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 193 | Opiate m (OP3, MOP) (human) (10μM**) | % Inhibition at Opiate m (OP3, MOP) (human) as reported by MDS | | Integer | % | |
| 194 | Opiate m (OP3, MOP) (human) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 195 | Opiate m (OP3, MOP) (human) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 196 | Opiate m (OP3, MOP) (human) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 197 | Phorbol Ester (mouse) (10μM**) | % Inhibition at Phorbol Ester (mouse) as reported by MDS | | Integer | % | |
| 198 | Phorbol Ester (mouse) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 199 | Phorbol Ester (mouse) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 200 | Phorbol Ester (mouse) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 201 | Platelet Activating Factor (PAF) (human) (10μM**) | % Inhibition at Platelet Activating Factor (PAF) (human) as reported by MDS | | Integer | % | |
| 202 | Platelet Activating Factor (PAF) (human) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 203 | Platelet Activating Factor (PAF) (human) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 204 | Platelet Activating Factor (PAF) (human) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 205 | Potassium Channel [K ATP] (hamster) (10μM**) | % Inhibition at Potassium Channel [K ATP] (hamster) as reported by MDS | | Integer | % | |
| 206 | Potassium Channel [K ATP] (hamster) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 207 | Potassium Channel [K ATP] (hamster) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 208 | Potassium Channel [K ATP] (hamster) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 209 | Potassium Channel hERG (human) (10μM**) | % Inhibition at Potassium Channel hERG (human) as reported by MDS | | Integer | % | |
| 210 | Potassium Channel hERG (human) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 211 | Potassium Channel hERG (human) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 212 | Potassium Channel hERG (human) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 213 | Prostanoid EP4 (human) (10μM**) | % Inhibition at Prostanoid EP4 (human) as reported by MDS | | Integer | % | |
| 214 | Prostanoid EP4 (human) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 215 | Prostanoid EP4 (human) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 216 | Prostanoid EP4 (human) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 217 | Purinergic P2X (rabbit) (10μM**) | % Inhibition at Purinergic P2X (rabbit) as reported by MDS | | Integer | % | |
| 218 | Purinergic P2X (rabbit) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 219 | Purinergic P2X (rabbit) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 220 | Purinergic P2X (rabbit) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 221 | Purinergic P2Y (rat) (10μM**) | % Inhibition at Purinergic P2Y (rat) as reported by MDS | | Integer | % | |
| 222 | Purinergic P2Y (rat) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 223 | Purinergic P2Y (rat) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 224 | Purinergic P2Y (rat) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 225 | Rolipram (rat) (10μM**) | % Inhibition at Rolipram (rat) as reported by MDS | | Integer | % | |
| 226 | Rolipram (rat) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 227 | Rolipram (rat) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 228 | Rolipram (rat) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 229 | Serotonin (5-Hydroxytryptamine) 5-HT1A (human) (10μM**) | % Inhibition at Serotonin (5-Hydroxytryptamine) 5-HT1A (human) as reported by MDS | | Integer | % | |
| 230 | Serotonin (5-Hydroxytryptamine) 5-HT1A (human) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 231 | Serotonin (5-Hydroxytryptamine) 5-HT1A (human) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 232 | Serotonin (5-Hydroxytryptamine) 5-HT1A (human) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 233 | Serotonin (5-Hydroxytryptamine) 5-HT3 (human) (10μM**) | % Inhibition at Serotonin (5-Hydroxytryptamine) 5-HT3 (human) as reported by MDS | | Integer | % | |
| 234 | Serotonin (5-Hydroxytryptamine) 5-HT3 (human) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 235 | Serotonin (5-Hydroxytryptamine) 5-HT3 (human) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 236 | Serotonin (5-Hydroxytryptamine) 5-HT3 (human) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 237 | Sigma s1 (human) (10μM**) | % Inhibition at Sigma s1 (human) as reported by MDS | | Integer | % | |
| 238 | Sigma s1 (human) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 239 | Sigma s1 (human) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 240 | Sigma s1 (human) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 241 | Sigma s2 (rat) (10μM**) | % Inhibition at Sigma s2 (rat) as reported by MDS | | Integer | % | |
| 242 | Sigma s2 (rat) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 243 | Sigma s2 (rat) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 244 | Sigma s2 (rat) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 245 | Sodium Channel, Site 2 (rat) (10μM**) | % Inhibition at Sodium Channel, Site 2 (rat) as reported by MDS | | Integer | % | |
| 246 | Sodium Channel, Site 2 (rat) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 247 | Sodium Channel, Site 2 (rat) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 248 | Sodium Channel, Site 2 (rat) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 249 | Tachykinin NK1 (human) (10μM**) | % Inhibition at Tachykinin NK1 (human) as reported by MDS | | Integer | % | |
| 250 | Tachykinin NK1 (human) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 251 | Tachykinin NK1 (human) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 252 | Tachykinin NK1 (human) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 253 | Thyroid Hormone (rat) (10μM**) | % Inhibition at Thyroid Hormone (rat) as reported by MDS | | Integer | % | |
| 254 | Thyroid Hormone (rat) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 255 | Thyroid Hormone (rat) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 256 | Thyroid Hormone (rat) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 257 | Transporter, Dopamine (DAT) (human) (10μM**) | % Inhibition at Transporter, Dopamine (DAT) (human) as reported by MDS | | Integer | % | |
| 258 | Transporter, Dopamine (DAT) (human) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 259 | Transporter, Dopamine (DAT) (human) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 260 | Transporter, Dopamine (DAT) (human) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 261 | Transporter, GABA (rat) (10μM**) | % Inhibition at Transporter, GABA (rat) as reported by MDS | | Integer | % | |
| 262 | Transporter, GABA (rat) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 263 | Transporter, GABA (rat) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 264 | Transporter, GABA (rat) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 265 | Transporter, Norepinephrine (NET) (human) (10μM**) | % Inhibition at Transporter, Norepinephrine (NET) (human) as reported by MDS | | Integer | % | |
| 266 | Transporter, Norepinephrine (NET) (human) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 267 | Transporter, Norepinephrine (NET) (human) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 268 | Transporter, Norepinephrine (NET) (human) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String | ||
| 269 | Transporter, Serotonin (5-Hydroxytryptamine) (SERT) (human) (10μM**) | % Inhibition at Transporter, Serotonin (5-Hydroxytryptamine) (SERT) (human) as reported by MDS | | Integer | % | |
| 270 | Transporter, Serotonin (5-Hydroxytryptamine) (SERT) (human) gene_ID† | gene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | String | |||
| 271 | Transporter, Serotonin (5-Hydroxytryptamine) (SERT) (human) protein gi | protein gi as found at http://www.ncbi.nlm.nih.gov/protein/ | Protein gi | String | ||
| 272 | Transporter, Serotonin (5-Hydroxytryptamine) (SERT) (human) tax_id | taxon reference ID as recorded under "source" within each protein gi record | Target taxonomy ID | String |
† RNAi Target. ** Test Concentration.
Additional Information
Grant Number: R21 NS057041-01
Data Table (Concise)
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