Bookmark and Share
BioAssay: AID 1793

Identification of Novel Modulators of Cl- dependent Transport Process via HTS: Antagonist Ancillary Profile

Cation-chloride cotransporters such as K-Cl cotransport and Na-K-2Cl cotransport play major roles in a variety of physiological settings, including the modulation of GABAergic synaptic transmission. For instance, KCC2, a neuronal-specific K-Cl cotransporter is up-regulated in the brain during postnatal development, and is responsible for lowering the intracellular Cl- concentration in neurons, more ..
_
   
 Tested Compounds
 Tested Compounds
All(1)
 
 
Unspecified(1)
 
 
 Tested Substances
 Tested Substances
All(1)
 
 
Unspecified(1)
 
 
 Related BioAssays
 Related BioAssays
AID: 1793
Data Source: Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters (ED001_Antag_MDS)
Depositor Category: NIH Molecular Libraries Screening Center Network
Deposit Date: 2009-05-28

Data Table ( Complete ):           All
Tested Compound:
Depositor Specified Assays
AIDNameTypeComment
1717Identification of Novel Modulators of Cl- dependent Transport Process via HTS: Retesting of KCC2 cells with OuabainotherIdentification of Novel Modulators of Cl- dependent Transport Process via HTS: Retesting of KCC2 cells with Ouabain
1456Identification of Novel Modulators of Cl- dependent Transport Process via HTS: Primary ScreenotherIdentification of Novel Modulators of Cl- dependent Transport Process via HTS: Primary Screen.##
1799Identification of Novel Modulators of Cl- dependent Transport Process via HTS: Antagonist Probe Summarysummary
Description:
Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters
Assay Provider: Eric Delpire
Assay Provider Affliation: Vanderbilt University
Grant Title: Identification of Novel Modulators of Cl- dependent Transport Process via HTS
Grant Number: R21NS053658-01

Cation-chloride cotransporters such as K-Cl cotransport and Na-K-2Cl cotransport play major roles in a variety of physiological settings, including the modulation of GABAergic synaptic transmission. For instance, KCC2, a neuronal-specific K-Cl cotransporter is up-regulated in the brain during postnatal development, and is responsible for lowering the intracellular Cl- concentration in neurons, thus promoting GABA inhibition. Reduction in KCC2 expression results in brain hyperexcitability, as demonstrated by animal models. Furthermore, KCC2 expression is decreased in brain tissue isolated from epileptic patients.

There are very few pharmacological agents that affect K-Cl cotransporters. First, there are no specific inhibitors of K-Cl cotransporters. Furosemide is mostly used to inhibit K-Cl cotransporter function, but the diuretic is not very potent and is not specific as it inhibits the Na-K-2Cl cotransporter (diuretic effect), many Cl- channels including the GABAA receptor. Finding new inhibitors will provide important tools for the study of KCC2 in modulating inhibitory neurotransmission. Second, there are also no compounds known to activate K-Cl cotransporter, except for N-ethylmaleimide, which affects many cellular processes as an unspecific alkylating agent. Finding a specific agent that increase KCC2 function would potentially have therapeutic value, as increased KCC2 function reduces susceptibility to epileptic seizures.
Protocol
The purpose of this assay was to test the lead compound against a broad panel of targets to determine ancillary activity.

MDS Pharma (The Triad, 2200 Renaissance Blvd, Suite 400, King of Prussia, PA 19406-2755) performed a Lead Profiling Screen of GPCRs, ion channels and transporters against the compound at 10uM concentration. The compond possessed a superior ancillary profile with no activities >50% at 10 uM, and was thus declared an MLPCN probe.
Result Definitions
Show more
TIDNameDescriptionAnnotationHistogramTypeUnit
OutcomeThe BioAssay activity outcomeOutcome
1Adenosine A1 (human) (10μM**)% Inhibition at Adenosine A1 (human) as reported by MDSInteger%
2Adenosine A1 (human) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
3Adenosine A1 (human) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
4Adenosine A1 (human) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
5Adenosine A2 (human) (10μM**)% Inhibition at Adenosine A2 (human) as reported by MDSInteger%
6Adenosine A2 (human) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
7Adenosine A2 (human) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
8Adenosine A2 (human) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
9Adenosine A3 (human) (10μM**)% Inhibition at Adenosine A3 (human) as reported by MDSInteger%
10Adenosine A3 (human) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
11Adenosine A3 (human) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
12Adenosine A3 (human) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
13Adrenergic a1A (rat) (10μM**)% Inhibition at Adrenergic a1A (rat) as reported by MDSInteger%
14Adrenergic a1A (rat) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
15Adrenergic a1A (rat) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
16Adrenergic a1A (rat) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
17Adrenergic a1B (rat) (10μM**)% Inhibition at Adrenergic a1B (rat) as reported by MDSInteger%
18Adrenergic a1B (rat) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
19Adrenergic a1B (rat) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
20Adrenergic a1B (rat) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
21Adrenergic a1D (human) (10μM**)% Inhibition at Adrenergic a1D (human) as reported by MDSInteger%
22Adrenergic a1D (human) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
23Adrenergic a1D (human) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
24Adrenergic a1D (human) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
25Adrenergic a2A (human) (10μM**)% Inhibition at Adrenergic a2A (human) as reported by MDSInteger%
26Adrenergic a2A (human) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
27Adrenergic a2A (human) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
28Adrenergic a2A (human) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
29Adrenergic b1 (human) (10μM**)% Inhibition at Adrenergic b1 (human) as reported by MDSInteger%
30Adrenergic b1 (human) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
31Adrenergic b1 (human) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
32Adrenergic b1 (human) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
33Adrenergic b2 (human) (10μM**)% Inhibition at Adrenergic b2 (human) as reported by MDSInteger%
34Adrenergic b2 (human) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
35Adrenergic b2 (human) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
36Adrenergic b2 (human) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
37Androgen (testosterone)AR (rat) (10μM**)% Inhibition at Androgen (testosterone)AR (rat) as reported by MDSInteger%
38Androgen (testosterone)AR (rat) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
39Androgen (testosterone)AR (rat) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
40Androgen (testosterone)AR (rat) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
41Bradykinin B1 (human) (10μM**)% Inhibition at Bradykinin B1 (human) as reported by MDSInteger%
42Bradykinin B1 (human) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
43Bradykinin B1 (human) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
44Bradykinin B1 (human) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
45Bradykinin B2 (human) (10μM**)% Inhibition at Bradykinin B2 (human) as reported by MDSInteger%
46Bradykinin B2 (human) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
47Bradykinin B2 (human) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
48Bradykinin B2 (human) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
49Calcium channel L -type, benzothiazepine (rat) (10μM**)% Inhibition at Calcium channel L -type, benzothiazepine (rat) as reported by MDSInteger%
50Calcium channel L -type, benzothiazepine (rat) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
51Calcium channel L -type, benzothiazepine (rat) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
52Calcium channel L -type, benzothiazepine (rat) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
53Calcium channel L -type, dihydropyridine (rat) (10μM**)% Inhibition at Calcium channel L -type, dihydropyridine (rat) as reported by MDSInteger%
54Calcium channel L -type, dihydropyridine (rat) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
55Calcium channel L -type, dihydropyridine (rat) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
56Calcium channel L -type, dihydropyridine (rat) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
57Calcium channel N-type (rat) (10μM**)% Inhibition at Calcium channel N-type (rat) as reported by MDSInteger%
58Calcium channel N-type (rat) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
59Calcium channel N-type (rat) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
60Calcium channel N-type (rat) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
61Dopamine D 1 (human) (10μM**)% Inhibition at Dopamine D 1 (human) as reported by MDSInteger%
62Dopamine D 1 (human) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
63Dopamine D 1 (human) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
64Dopamine D 1 (human) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
65Dopamine D 2S (human) (10μM**)% Inhibition at Dopamine D 2S (human) as reported by MDSInteger%
66Dopamine D 2S (human) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
67Dopamine D 2S (human) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
68Dopamine D 2S (human) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
69Dopamine D 4.2 (human) (10μM**)% Inhibition at Dopamine D 4.2 (human) as reported by MDSInteger%
70Dopamine D 4.2 (human) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
71Dopamine D 4.2 (human) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
72Dopamine D 4.2 (human) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
73Dopamine D3 (human) (10μM**)% Inhibition at Dopamine D3 (human) as reported by MDSInteger%
74Dopamine D3 (human) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
75Dopamine D3 (human) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
76Dopamine D3 (human) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
77Endothelin ETA (human) (10μM**)% Inhibition at Endothelin ETA (human) as reported by MDSInteger%
78Endothelin ETA (human) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
79Endothelin ETA (human) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
80Endothelin ETA (human) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
81Endothelin ETB (human) (10μM**)% Inhibition at Endothelin ETB (human) as reported by MDSInteger%
82Endothelin ETB (human) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
83Endothelin ETB (human) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
84Endothelin ETB (human) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
85Epidermal Growth Factor (EGF) (human) (10μM**)% Inhibition at Epidermal Growth Factor (EGF) (human) as reported by MDSInteger%
86Epidermal Growth Factor (EGF) (human) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
87Epidermal Growth Factor (EGF) (human) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
88Epidermal Growth Factor (EGF) (human) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
89Estrogen ER a (human) (10μM**)% Inhibition at Estrogen ER a (human) as reported by MDSInteger%
90Estrogen ER a (human) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
91Estrogen ER a (human) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
92Estrogen ER a (human) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
93G protein-coupled receptor GPR103 (human) (10μM**)% Inhibition at G protein-coupled receptor GPR103 (human) as reported by MDSInteger%
94G protein-coupled receptor GPR103 (human) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
95G protein-coupled receptor GPR103 (human) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
96G protein-coupled receptor GPR103 (human) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
97GABA B1A (human) (10μM**)% Inhibition at GABA B1A (human) as reported by MDSInteger%
98GABA B1A (human) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
99GABA B1A (human) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
100GABA B1A (human) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
101GABAAFlunitrazepam, central (rat) (10μM**)% Inhibition at GABAAFlunitrazepam, central (rat) as reported by MDSInteger%
102GABAAFlunitrazepam, central (rat) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
103GABAAFlunitrazepam, central (rat) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
104GABAAFlunitrazepam, central (rat) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
105GABAAMuscimol, central (rat) (10μM**)% Inhibition at GABAAMuscimol, central (rat) as reported by MDSInteger%
106GABAAMuscimol, central (rat) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
107GABAAMuscimol, central (rat) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
108GABAAMuscimol, central (rat) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
109Glucocorticoid (human) (10μM**)% Inhibition at Glucocorticoid (human) as reported by MDSInteger%
110Glucocorticoid (human) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
111Glucocorticoid (human) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
112Glucocorticoid (human) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
113Glutamate, Kainate (rat) (10μM**)% Inhibition at Glutamate, Kainate (rat) as reported by MDSInteger%
114Glutamate, Kainate (rat) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
115Glutamate, Kainate (rat) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
116Glutamate, Kainate (rat) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
117Glutamate, NMDA, Agonism (rat) (10μM**)% Inhibition at Glutamate, NMDA, Agonism (rat) as reported by MDSInteger%
118Glutamate, NMDA, Agonism (rat) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
119Glutamate, NMDA, Agonism (rat) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
120Glutamate, NMDA, Agonism (rat) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
121Glutamate, NMDA, Glycine (rat) (10μM**)% Inhibition at Glutamate, NMDA, Glycine (rat) as reported by MDSInteger%
122Glutamate, NMDA, Glycine (rat) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
123Glutamate, NMDA, Glycine (rat) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
124Glutamate, NMDA, Glycine (rat) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
125Glutamate, NMDA, Phencyclidine (rat) (10μM**)% Inhibition at Glutamate, NMDA, Phencyclidine (rat) as reported by MDSInteger%
126Glutamate, NMDA, Phencyclidine (rat) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
127Glutamate, NMDA, Phencyclidine (rat) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
128Glutamate, NMDA, Phencyclidine (rat) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
129Histamine H1 (human) (10μM**)% Inhibition at Histamine H1 (human) as reported by MDSInteger%
130Histamine H1 (human) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
131Histamine H1 (human) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
132Histamine H1 (human) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
133Histamine H2 (human) (10μM**)% Inhibition at Histamine H2 (human) as reported by MDSInteger%
134Histamine H2 (human) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
135Histamine H2 (human) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
136Histamine H2 (human) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
137Histamine H3 (human) (10μM**)% Inhibition at Histamine H3 (human) as reported by MDSInteger%
138Histamine H3 (human) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
139Histamine H3 (human) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
140Histamine H3 (human) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
141Imidazoline I2, central (rat) (10μM**)% Inhibition at Imidazoline I2, central (rat) as reported by MDSInteger%
142Imidazoline I2, central (rat) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
143Imidazoline I2, central (rat) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
144Imidazoline I2, central (rat) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
145Interleukin IL-1 (mouse) (10μM**)% Inhibition at Interleukin IL-1 (mouse) as reported by MDSInteger%
146Interleukin IL-1 (mouse) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
147Interleukin IL-1 (mouse) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
148Interleukin IL-1 (mouse) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
149Leukotriene, Cysteinyl CysLT1 (human) (10μM**)% Inhibition at Leukotriene, Cysteinyl CysLT1 (human) as reported by MDSInteger%
150Leukotriene, Cysteinyl CysLT1 (human) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
151Leukotriene, Cysteinyl CysLT1 (human) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
152Leukotriene, Cysteinyl CysLT1 (human) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
153Melatonin MT1 (human) (10μM**)% Inhibition at Melatonin MT1 (human) as reported by MDSInteger%
154Melatonin MT1 (human) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
155Melatonin MT1 (human) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
156Melatonin MT1 (human) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
157Muscarinic M1 (human) (10μM**)% Inhibition at Muscarinic M1 (human) as reported by MDSInteger%
158Muscarinic M1 (human) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
159Muscarinic M1 (human) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
160Muscarinic M1 (human) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
161Muscarinic M2 (human) (10μM**)% Inhibition at Muscarinic M2 (human) as reported by MDSInteger%
162Muscarinic M2 (human) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
163Muscarinic M2 (human) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
164Muscarinic M2 (human) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
165Muscarinic M3 (human) (10μM**)% Inhibition at Muscarinic M3 (human) as reported by MDSInteger%
166Muscarinic M3 (human) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
167Muscarinic M3 (human) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
168Muscarinic M3 (human) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
169Neuropeptide Y Y1 (human) (10μM**)% Inhibition at Neuropeptide Y Y1 (human) as reported by MDSInteger%
170Neuropeptide Y Y1 (human) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
171Neuropeptide Y Y1 (human) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
172Neuropeptide Y Y1 (human) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
173Neuropeptide Y Y2 (human) (10μM**)% Inhibition at Neuropeptide Y Y2 (human) as reported by MDSInteger%
174Neuropeptide Y Y2 (human) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
175Neuropeptide Y Y2 (human) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
176Neuropeptide Y Y2 (human) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
177Nicotinic Acetylcholine (human) (10μM**)% Inhibition at Nicotinic Acetylcholine (human) as reported by MDSInteger%
178Nicotinic Acetylcholine (human) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
179Nicotinic Acetylcholine (human) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
180Nicotinic Acetylcholine (human) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
181Nicotinic Acetylcholine 1 a , Bungarotoxin (human) (10μM**)% Inhibition at Nicotinic Acetylcholine 1 a , Bungarotoxin (human) as reported by MDSInteger%
182Nicotinic Acetylcholine 1 a , Bungarotoxin (human) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
183Nicotinic Acetylcholine 1 a , Bungarotoxin (human) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
184Nicotinic Acetylcholine 1 a , Bungarotoxin (human) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
185Opiate d (OP1, DOP) (human) (10μM**)% Inhibition at Opiate d (OP1, DOP) (human) as reported by MDSInteger%
186Opiate d (OP1, DOP) (human) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
187Opiate d (OP1, DOP) (human) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
188Opiate d (OP1, DOP) (human) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
189Opiate k (OP2, KOP) (human) (10μM**)% Inhibition at Opiate k (OP2, KOP) (human) as reported by MDSInteger%
190Opiate k (OP2, KOP) (human) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
191Opiate k (OP2, KOP) (human) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
192Opiate k (OP2, KOP) (human) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
193Opiate m (OP3, MOP) (human) (10μM**)% Inhibition at Opiate m (OP3, MOP) (human) as reported by MDSInteger%
194Opiate m (OP3, MOP) (human) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
195Opiate m (OP3, MOP) (human) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
196Opiate m (OP3, MOP) (human) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
197Phorbol Ester (mouse) (10μM**)% Inhibition at Phorbol Ester (mouse) as reported by MDSInteger%
198Phorbol Ester (mouse) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
199Phorbol Ester (mouse) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
200Phorbol Ester (mouse) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
201Platelet Activating Factor (PAF) (human) (10μM**)% Inhibition at Platelet Activating Factor (PAF) (human) as reported by MDSInteger%
202Platelet Activating Factor (PAF) (human) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
203Platelet Activating Factor (PAF) (human) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
204Platelet Activating Factor (PAF) (human) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
205Potassium Channel [K ATP] (hamster) (10μM**)% Inhibition at Potassium Channel [K ATP] (hamster) as reported by MDSInteger%
206Potassium Channel [K ATP] (hamster) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
207Potassium Channel [K ATP] (hamster) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
208Potassium Channel [K ATP] (hamster) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
209Potassium Channel hERG (human) (10μM**)% Inhibition at Potassium Channel hERG (human) as reported by MDSInteger%
210Potassium Channel hERG (human) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
211Potassium Channel hERG (human) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
212Potassium Channel hERG (human) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
213Prostanoid EP4 (human) (10μM**)% Inhibition at Prostanoid EP4 (human) as reported by MDSInteger%
214Prostanoid EP4 (human) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
215Prostanoid EP4 (human) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
216Prostanoid EP4 (human) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
217Purinergic P2X (rabbit) (10μM**)% Inhibition at Purinergic P2X (rabbit) as reported by MDSInteger%
218Purinergic P2X (rabbit) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
219Purinergic P2X (rabbit) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
220Purinergic P2X (rabbit) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
221Purinergic P2Y (rat) (10μM**)% Inhibition at Purinergic P2Y (rat) as reported by MDSInteger%
222Purinergic P2Y (rat) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
223Purinergic P2Y (rat) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
224Purinergic P2Y (rat) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
225Rolipram (rat) (10μM**)% Inhibition at Rolipram (rat) as reported by MDSInteger%
226Rolipram (rat) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
227Rolipram (rat) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
228Rolipram (rat) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
229Serotonin (5-Hydroxytryptamine) 5-HT1A (human) (10μM**)% Inhibition at Serotonin (5-Hydroxytryptamine) 5-HT1A (human) as reported by MDSInteger%
230Serotonin (5-Hydroxytryptamine) 5-HT1A (human) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
231Serotonin (5-Hydroxytryptamine) 5-HT1A (human) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
232Serotonin (5-Hydroxytryptamine) 5-HT1A (human) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
233Serotonin (5-Hydroxytryptamine) 5-HT3 (human) (10μM**)% Inhibition at Serotonin (5-Hydroxytryptamine) 5-HT3 (human) as reported by MDSInteger%
234Serotonin (5-Hydroxytryptamine) 5-HT3 (human) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
235Serotonin (5-Hydroxytryptamine) 5-HT3 (human) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
236Serotonin (5-Hydroxytryptamine) 5-HT3 (human) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
237Sigma s1 (human) (10μM**)% Inhibition at Sigma s1 (human) as reported by MDSInteger%
238Sigma s1 (human) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
239Sigma s1 (human) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
240Sigma s1 (human) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
241Sigma s2 (rat) (10μM**)% Inhibition at Sigma s2 (rat) as reported by MDSInteger%
242Sigma s2 (rat) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
243Sigma s2 (rat) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
244Sigma s2 (rat) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
245Sodium Channel, Site 2 (rat) (10μM**)% Inhibition at Sodium Channel, Site 2 (rat) as reported by MDSInteger%
246Sodium Channel, Site 2 (rat) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
247Sodium Channel, Site 2 (rat) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
248Sodium Channel, Site 2 (rat) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
249Tachykinin NK1 (human) (10μM**)% Inhibition at Tachykinin NK1 (human) as reported by MDSInteger%
250Tachykinin NK1 (human) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
251Tachykinin NK1 (human) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
252Tachykinin NK1 (human) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
253Thyroid Hormone (rat) (10μM**)% Inhibition at Thyroid Hormone (rat) as reported by MDSInteger%
254Thyroid Hormone (rat) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
255Thyroid Hormone (rat) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
256Thyroid Hormone (rat) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
257Transporter, Dopamine (DAT) (human) (10μM**)% Inhibition at Transporter, Dopamine (DAT) (human) as reported by MDSInteger%
258Transporter, Dopamine (DAT) (human) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
259Transporter, Dopamine (DAT) (human) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
260Transporter, Dopamine (DAT) (human) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
261Transporter, GABA (rat) (10μM**)% Inhibition at Transporter, GABA (rat) as reported by MDSInteger%
262Transporter, GABA (rat) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
263Transporter, GABA (rat) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
264Transporter, GABA (rat) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
265Transporter, Norepinephrine (NET) (human) (10μM**)% Inhibition at Transporter, Norepinephrine (NET) (human) as reported by MDSInteger%
266Transporter, Norepinephrine (NET) (human) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
267Transporter, Norepinephrine (NET) (human) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
268Transporter, Norepinephrine (NET) (human) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString
269Transporter, Serotonin (5-Hydroxytryptamine) (SERT) (human) (10μM**)% Inhibition at Transporter, Serotonin (5-Hydroxytryptamine) (SERT) (human) as reported by MDSInteger%
270Transporter, Serotonin (5-Hydroxytryptamine) (SERT) (human) gene_IDgene ID as found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=geneString
271Transporter, Serotonin (5-Hydroxytryptamine) (SERT) (human) protein giprotein gi as found at http://www.ncbi.nlm.nih.gov/protein/Protein giString
272Transporter, Serotonin (5-Hydroxytryptamine) (SERT) (human) tax_idtaxon reference ID as recorded under "source" within each protein gi recordTarget taxonomy IDString

RNAi Target. ** Test Concentration.
Additional Information
Grant Number: R21NS053658-01

Data Table (Concise)
Classification
PageFrom: