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BioAssay: AID 161005

Inhibition of Prostaglandin G/H synthase in intact RBL-1 cell line

Title: Nonsteroidal antiinflammatory drug hydroxamic acids. Dual inhibitors of both cyclooxygenase and 5-lipoxygenase.
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 Tested Compounds
 Tested Compounds
All(17)
 
 
Active(13)
 
 
Inactive(1)
 
 
Unspecified(3)
 
 
 Tested Substances
 Tested Substances
All(17)
 
 
Active(13)
 
 
Inactive(1)
 
 
Unspecified(3)
 
 
 Related BioAssays
 Related BioAssays
AID: 161005
Data Source: ChEMBL (158264)
BioAssay Type: Confirmatory, Concentration-Response Relationship Observed
Depositor Category: Literature, Extracted
BioAssay Version:
Deposit Date: 2010-05-21
Modify Date: 2014-05-19

Data Table ( Complete ):           View Active Data    View All Data
BioActive Compounds: 13
Description:
Title: Nonsteroidal antiinflammatory drug hydroxamic acids. Dual inhibitors of both cyclooxygenase and 5-lipoxygenase.
(PMID: 2115586)
Comment
Compounds with activity <= 50uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Putative Target:

ChEMBL Target ID: 104742
Target Type: PROTEIN FAMILY
Pref Name: Cyclooxygenase
Synonyms: COX-1;Cyclooxygenase-1;PGH synthase 1;PGHS-1;PHS 1;Prostaglandin G/H synthase 1;Prostaglandin H2 synthase 1;Prostaglandin-endoperoxide synthase 1;COX-2;Cyclooxygenase-2;PGH synthase 2;PGHS-2;PHS II;Prostaglandin G/H synthase 2;Prostaglandin H2 synthase 2;Prostaglandin-endoperoxide synthase 2;
Gene Name: Cox-1 ;Cox1;Ptgs1;Cox-2 ;Cox2;Ptgs2;
Protein Accession: Q63921;P35355;
Protein GI: 3914292;548484;
Organism: Rattus norvegicus
Tax ID: 10116
Target Classification: enzyme
Confidence: Multiple homologous protein targets may be assigned
Relationship Type: Homologous protein target assigned
Categorized Comment
Assay Type: Binding

Assay Data Source: Scientific Literature

BAO: Assay Format: cell-based format

Assay Cell Type: RBL-1

Result Definitions
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TIDNameDescriptionHistogramTypeUnit
OutcomeThe BioAssay activity outcomeOutcome
1IC50*IC50 PubChem standard valueFloatμM
3BEIBinding Efficiency Index(nM)Float
2SEISurface Efficiency Index(nM)Float
4LELigand EfficiencyFloat
5LLELipophilic Ligand EfficiencyFloat
6IC50 activity commentIC50 activity commentString
7IC50 standard flagIC50 standard flagInteger
8IC50 qualifierIC50 qualifierString
9IC50 published valueIC50 published valueFloatμM
10IC50 standard valueIC50 standard valueFloatnM

* Activity Concentration.

Data Table (Concise)
Data Table ( Complete ):     View Active Data    View All Data
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