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BioAssay: AID 150495

Antagonist activity against phospholipase C coupled rat P2Y purinoceptor 12 (P2Y12)

Title: Purine and pyrimidine (P2) receptors as drug targets.
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 Tested Compounds
 Tested Compounds
All(12)
 
 
Active(7)
 
 
Unspecified(5)
 
 
 Tested Substances
 Tested Substances
All(12)
 
 
Active(7)
 
 
Unspecified(5)
 
 
 Related BioAssays
 Related BioAssays
AID: 150495
Data Source: ChEMBL (147742)
BioAssay Type: Confirmatory, Concentration-Response Relationship Observed
Depositor Category: Literature, Extracted
BioAssay Version:
Deposit Date: 2010-05-24
Modify Date: 2014-12-06

Data Table ( Complete ):           View Active Data    View All Data
BioActive Compounds: 7
Description:
Title: Purine and pyrimidine (P2) receptors as drug targets.
(PMID: 12213051)
Comment
Compounds with activity <= 50uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.
Putative Target:
ChEMBL Target ID: 11000
Target Type: SINGLE PROTEIN
Pref Name: Purinergic receptor P2Y12
Synonyms: P2Y purinoceptor 12;P2Y12;P2Y12 platelet ADP receptor;
Gene Name: P2ry12;P2y12;
Protein Accession: Q9EPX4;
Protein GI: 21263800;
Organism: Rattus norvegicus
Tax ID: 10116
Target Classification: membrane receptor 7tm1 smallmol nucleotide-like receptor purine receptor
Confidence: Homologous single protein target assigned
Relationship Type: Homologous protein target assigned
Categorized Comment - additional comments and annotations
From ChEMBL:
Assay Type: Functional
Assay Data Source: Scientific Literature
Result Definitions
TIDNameDescriptionHistogramTypeUnit
OutcomeThe BioAssay activity outcomeOutcome
1EC50*EC50 PubChem standard valueFloatμM
2EC50 activity commentEC50 activity commentString
3EC50 standard flagEC50 standard flagInteger
4EC50 qualifierEC50 qualifierString
5EC50 published valueEC50 published valueFloatnM
6EC50 standard valueEC50 standard valueFloatnM

* Activity Concentration.

Data Table (Concise)
Data Table ( Complete ):     View Active Data    View All Data
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