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BioAssay: AID 150172

Antagonist activity against recombinant rat P2X purinoceptor 6 (P2X6 )

Title: Purine and pyrimidine (P2) receptors as drug targets.
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 Tested Compounds
 Tested Compounds
All(7)
 
 
Active(4)
 
 
Unspecified(3)
 
 
 Tested Substances
 Tested Substances
All(7)
 
 
Active(4)
 
 
Unspecified(3)
 
 
 Related BioAssays
 Related BioAssays
AID: 150172
Data Source: ChEMBL (147419)
BioAssay Type: Confirmatory, Concentration-Response Relationship Observed
Depositor Category: Literature, Extracted
BioAssay Version:
Deposit Date: 2010-05-24
Modify Date: 2014-05-20

Data Table ( Complete ):           Active    All
BioActive Compounds: 4
Description:
Title: Purine and pyrimidine (P2) receptors as drug targets.
(PMID: 12213051)
Comment
Compounds with activity <= 50uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Putative Target:

ChEMBL Target ID: 10539
Target Type: SINGLE PROTEIN
Pref Name: P2X purinoceptor 6
Synonyms: ATP receptor;P2X purinoceptor 6;P2X6;P2XM;Purinergic receptor;Purinergic receptor P2X-like 1;
Gene Name: P2rx6;P2rxl1;
Protein Accession: P51579;
Protein GI: 1709523;
Organism: Rattus norvegicus
Tax ID: 10116
Target Classification: ion channel lgic p2x
Confidence: Homologous single protein target assigned
Relationship Type: Homologous protein target assigned
Categorized Comment
Assay Type: Functional

Assay Data Source: Scientific Literature

Result Definitions
TIDNameDescriptionHistogramTypeUnit
OutcomeThe BioAssay activity outcomeOutcome
1EC50*EC50 PubChem standard valueFloatμM
2EC50 activity commentEC50 activity commentString
3EC50 standard flagEC50 standard flagInteger
4EC50 qualifierEC50 qualifierString
5EC50 published valueEC50 published valueFloatnM
6EC50 standard valueEC50 standard valueFloatnM

* Activity Concentration.

Data Table (Concise)
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