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BioAssay: AID 145657

Compound was evaluated for functional potencies and efficacies at rat Nicotinic acetylcholine receptor subtype PC12 (ganglionic)

Title: Neuronal nicotinic acetylcholine receptors as targets for drug discovery.
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 Tested Compounds
 Tested Compounds
All(7)
 
 
Active(4)
 
 
Unspecified(3)
 
 
 Tested Substances
 Tested Substances
All(7)
 
 
Active(4)
 
 
Unspecified(3)
 
 
 Related BioAssays
 Related BioAssays
AID: 145657
Data Source: ChEMBL (142900)
Depositor Category: Literature, Extracted
BioAssay Version:
Deposit Date: 2010-05-24
Modify Date: 2013-11-14

Data Table ( Complete ):           Active    All
BioActive Compounds: 4
Description:
Title: Neuronal nicotinic acetylcholine receptors as targets for drug discovery.
(PMID: 9435889)
Comment
Compounds with activity <= 50uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Putative Target:

ChEMBL Target ID: 19699
Target Type: SINGLE PROTEIN
Pref Name: Acetylcholine receptor protein delta chain
Synonyms: Acetylcholine receptor subunit delta;
Gene Name: CHNRD;
Protein Accession: P02718;
Protein GI: 113090;
Organism: Torpedo californica
Tax ID: 7787
Target Classification: ion channel lgic cys_loop ach cationic ns chrn delta
Confidence: Homologous single protein target assigned
Relationship Type: Homologous protein target assigned
Categorized Comment
ChEMBL Assay Type: Binding

ChEMBL Assay Data Source: Scientific Literature

Result Definitions
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TIDNameDescriptionHistogramTypeUnit
OutcomeThe BioAssay activity outcomeOutcome
1EC50*EC50 PubChem standard valueFloatμM
2BEIBinding Efficiency Index(nM)Float
3SEISurface Efficiency Index(nM)Float
4LELigand EfficiencyFloat
5LLELipophilic Ligand EfficiencyFloat
6EC50 activity commentEC50 activity commentString
7EC50 standard flagEC50 standard flagInteger
8EC50 qualifierEC50 qualifierString
9EC50 published valueEC50 published valueFloatμM
10EC50 standard valueEC50 standard valueFloatnM
11EC50 data validityEC50 data validityString

* Activity Concentration.

Data Table (Concise)
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