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BioAssay: AID 144825

Compound was evaluated for in vitro inhibition of [3H]TCP at NMDA receptor

Title: The glycine site on the NMDA receptor: structure-activity relationships and therapeutic potential.
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 Tested Compounds
 Tested Compounds
All(3)
 
 
Active(3)
 
 
 Tested Substances
 Tested Substances
All(3)
 
 
Active(3)
 
 
 Related BioAssays
 Related BioAssays
AID: 144825
Data Source: ChEMBL (142068)
BioAssay Type: Confirmatory, Concentration-Response Relationship Observed
Depositor Category: Literature, Extracted
BioAssay Version:
Deposit Date: 2010-05-21
Modify Date: 2014-05-19

Data Table ( Complete ):           View Active Data    View All Data
BioActive Compounds: 3
Description:
Title: The glycine site on the NMDA receptor: structure-activity relationships and therapeutic potential.
(PMID: 7990104)
Comment
Compounds with activity <= 50uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Putative Target:

ChEMBL Target ID: 104302
Target Type: PROTEIN COMPLEX GROUP
Pref Name: Glutamate NMDA receptor
Synonyms: GluN2D;Glutamate receptor ionotropic; NMDA 2D;Glutamate [NMDA] receptor subunit epsilon-4;N-methyl D-aspartate receptor subtype 2D;NMDAR2D;NR2D;GluN1;Glutamate receptor ionotropic; NMDA 1;Glutamate [NMDA] receptor subunit zeta-1;N-methyl-D-aspartate receptor subunit NR1;NMD-R1;GluN2A;Glutamate receptor ionotropic; NMDA 2A;Glutamate [NMDA] receptor subunit epsilon-1;N-methyl D-aspartate receptor subtype 2A;NMDAR2A;NR2A;GluN2B;Glutamate receptor ionotropic; NMDA 2B;Glutamate [NMDA] receptor subunit epsilon-2;N-methyl D-aspartate receptor subtype 2B;NMDAR2B;NR2B;GluN2C;Glutamate receptor ionotropic; NMDA 2C;Glutamate [NMDA] receptor subunit epsilon-3;N-methyl D-aspartate receptor subtype 2C;NMDAR2C;NR2C;GluN3A;Glutamate receptor chi-1;Glutamate receptor ionotropic; NMDA 3A;N-methyl-D-aspartate receptor;N-methyl-D-aspartate receptor subtype 3A;NMDAR-L;NMDAR-L1;NMDAR3A;NR3A;GluN3B;Glutamate receptor ionotropic; NMDA 3B;N-methyl-D-aspartate receptor subtype 3B;NMDAR3B;NR3B;
Gene Name: GluN2D;Grin2d;Grin1;Nmdar1;Grin2a;Grin2b;Grin2c;Grin3a;Grin3b;
Protein Accession: Q62645;P35439;Q00959;Q00960;Q00961;Q9R1M7;Q8VHN2;
Protein GI: 18202594;548379;3915771;548372;548374;51701631;51701630;
Organism: Rattus norvegicus
Tax ID: 10116
Target Classification: ion channel lgic glut nmda
Confidence: Multiple homologous protein targets may be assigned
Relationship Type: Homologous protein target assigned
Categorized Comment
Assay Type: Binding

Assay Data Source: Scientific Literature

BAO: Assay Format: biochemical format

Result Definitions
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TIDNameDescriptionHistogramTypeUnit
OutcomeThe BioAssay activity outcomeOutcome
1EC50*EC50 PubChem standard valueFloatμM
3BEIBinding Efficiency Index(nM)Float
2SEISurface Efficiency Index(nM)Float
4LELigand EfficiencyFloat
5LLELipophilic Ligand EfficiencyFloat
6EC50 activity commentEC50 activity commentString
7EC50 standard flagEC50 standard flagInteger
8EC50 qualifierEC50 qualifierString
9EC50 published valueEC50 published valueFloatμM
10EC50 standard valueEC50 standard valueFloatnM

* Activity Concentration.

Data Table (Concise)
Data Table ( Complete ):     View Active Data    View All Data
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