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BioAssay: AID 1208

DSSTox (CPDBAS) Carcinogenic Potency Database Summary Rat Bioassay Results

The Carcinogenic Potency Database (CPDB) is a unique and widely used international resource of the results of over 6500 chronic, long-term animal cancer tests on over 1500 chemical substances. The CPDB provides easy access to the bioassay literature, with qualitative and quantitative analyses of both positive and negative experiments that have been published over the past 50 years in the general more ..
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 Tested Compounds
 Tested Compounds
All(1189)
 
 
Active(576)
 
 
Inactive(613)
 
 
Unspecified(9)
 
 
 Tested Substances
 Tested Substances
All(1240)
 
 
Active(586)
 
 
Inactive(645)
 
 
Unspecified(9)
 
 
 Related BioAssays
 Related BioAssays
AID: 1208
Data Source: EPA DSSTox (DSSTox_AID2)
BioAssay Version:
Deposit Date: 2008-03-05
Modify Date: 2008-11-28

Data Table ( Complete ):           View Active Data    View All Data
BioActive Compounds: 576
Description:
The Carcinogenic Potency Database (CPDB) is a unique and widely used international resource of the results of over 6500 chronic, long-term animal cancer tests on over 1500 chemical substances. The CPDB provides easy access to the bioassay literature, with qualitative and quantitative analyses of both positive and negative experiments that have been published over the past 50 years in the general literature and by the National Cancer Institute/National Toxicology Program. The CPDB standardizes the diverse literature of cancer bioassays that vary widely in protocol, histopathological examination and nomenclature, and in the published author's choices of what information to provide in their papers. Results are reported in the CPDB for tests in rats, mice, hamsters, dogs, and nonhuman primates, and are based on the most positive result among all experiments for each sex-species. The DSSTox CPDBAS (all species) file incorporates data from the CPDB Summary Tables for the full list of over 1500 chemical substances tested in at least one species. Summary bioassay results for Rat (TD50, tumor sites, male, female, both sexes) are provided in the CPDB Summary Tables and the DSSTox CPDBAS file for over 1200 chemical substances.
Protocol
TD50 is a standardized quantitative measure of carcinogenic potency (analogous to an LD50) and is reported in the CPDB Summary Table for each species. Activity Score for actives is computed by mapping of LOG10 (1/TD50_Rat_mmol) activity values spanning range [MIN, MAX] onto Integer 1-100 Activity Score range, where 100 is highest potency and 1 is lowest: Activity Score = 100 * INTEGER[(log10(1/Activity) - MIN)/(MAX - MIN)]. If activity is reported but no TD50_Rat_mmol value is computed, such as for a mixture, the Activity Score is assigned the activity value "50". Activity Outcome is based on minimal evidence for or against activity: "active" indicates one or more TD50 and tumor site listed for one or more Rat carcinogenicity sex/species cell (Rat Male, Rat Female, Rat Both); "inactive" indicates no TD50 or tumor site listed AND one or more "no positive results" entry for one or more Rat carcinogenicity sex/species cell (i.e., one or more experiments are in CPDB, but none are positive); "unspecified" indicates that the only experiments in CPDB were conducted by the NCI/NTP, and the NCI/NTP evaluated the bioassay as inadequate. Activity Score = 0 for "inactive" and "unspecified". Target sites are reported for each sex-species group with a positive result in the CPDB on the basis of a positive author's opinion for the particular site, using all results from both the general literature and NCI/NTP bioassays. If a chemical has two or more target sites listed, the results may be from different experiments, and a single site may be a target organ in more than one experiment, as well. Blank entry in TargetSites field indicates no results reported.
Comment
DSSTox CPDBAS: Carcinogenic Potency Database (CPDB) Summary Tables - All Species

To access complete SD file and documentation, refer to the DSSTox CPDBAS Download Page

For more information and description pertaining to this assay, and for access to the complete CPDB, see the Carcinogenic Potency Database website. For a full listing of Data Plots (from which the CPDB Summary Table was derived) see CPDB Data Plots. For a complete list of references, see CPDB Publications by Topic or CPDB Publications by Year.
Result Definitions
TIDNameDescriptionHistogramTypeUnit
OutcomeThe BioAssay activity outcomeOutcome
ScoreThe BioAssay activity ranking scoreInteger
1TD50_Rat_mgTD50 is defined as: "that dose-rate in mg/kg body wt/day which, if administered chronically for the standard lifespan of the species, will halve the probability of remaining tumorless throughout that period" and is reported for a chemical in each species with a positive evaluation of carcinogenicity in at least one test. If there is only one positive test on the chemical in the species, then the most potent TD50 from that test is reported. If more than one experiment is positive, the reported TD50 is the harmonic mean of the most potent TD50 values from each positive experiment in the species.Floatmg/kg-bw/day
2TD50_Rat_mmolTD50_Rat_mmol = TD50_Rat_mg / MolecularWeight if the substance is represented by a single MW structure (i.e., not a mixture).Floatmmol/kg-bw/day
3TD50_Rat_NoteComments pertaining to the Rat TD50 (corresponding to footnote indices in the original CPDB Summary Table).String
4TargetSites_Rat_MaleTarget sites reported for Rat_Male with a positive result in the CPDB on the basis of a positive author's opinion for the particular site, using all results from both the general literature and NCI/NTP bioassays. For more information, see Protocol and CPDB Bioassay URL.String
5TargetSites_Rat_FemaleTarget sites reported for Rat_Female with a positive result in the CPDB on the basis of a positive author's opinion for the particular site, using all results from both the general literature and NCI/NTP bioassays. For more information, see Protocol and CPDB Bioassay URL.String
6TargetSites_Rat_BothSexesTarget sites reported for Rat_BothSexes (used for experiments where results in the general literature are reported only for males and females combined) with a positive author's opinion for the particular site. For more information, see Protocol and CPDB Bioassay URL.String

Data Table (Concise)
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