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BioAssay: AID 1194

DSSTox (CPDBAS) Carcinogenic Potency Database Salmonella Mutagenicity

The Carcinogenic Potency Database (CPDB) is a unique and widely used international resource of the results of over 6500 chronic, long-term animal cancer tests on over 1500 chemical substances. The CPDB provides easy access to the bioassay literature, with qualitative and quantitative analyses of both positive and negative experiments that have been published over the past 50 years in the general more ..
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 Tested Compounds
 Tested Compounds
All(832)
 
 
Active(395)
 
 
Inactive(438)
 
 
 Tested Substances
 Tested Substances
All(860)
 
 
Active(403)
 
 
Inactive(457)
 
 
 Related BioAssays
 Related BioAssays
AID: 1194
Data Source: EPA DSSTox (DSSTox_AID1)
BioAssay Version:
Deposit Date: 2008-03-05
Modify Date: 2008-11-25

Data Table ( Complete ):           View Active Data    View All Data
BioActive Compounds: 395
Description:
The Carcinogenic Potency Database (CPDB) is a unique and widely used international resource of the results of over 6500 chronic, long-term animal cancer tests on over 1500 chemical substances. The CPDB provides easy access to the bioassay literature, with qualitative and quantitative analyses of both positive and negative experiments that have been published over the past 50 years in the general literature and by the National Cancer Institute/National Toxicology Program. The CPDB standardizes the diverse literature of cancer bioassays that vary widely in protocol, histopathological examination and nomenclature, and in the published author's choices of what information to provide in their papers. Results are reported in the CPDB for tests in rats, mice, hamsters, dogs, and nonhuman primates, and are based on the most positive result among all experiments for each sex-species. The DSSTox CPDBAS (all species) file incorporates data from the CPDB Summary Tables for the full list of over 1500 chemical substances tested in at least one species. A summary mutagenicity call (active and inactive) is provided in the CPDB Summary Tables and the DSSTox CPDBAS file for over 850 chemical substances.
Protocol
A chemical is classified within the CPDB as mutagenic, i.e. "active", in the Salmonella assay if it was evaluated overall as either "mutagenic" or "weakly mutagenic" by Zeiger [Zeiger, E. (1997) Genotoxicity Database. In: Gold and Zeiger, Eds. Handbook of Carcinogenic Potency and Genotoxicity Databases. Boca Raton, FL: CRC Press, pp. 687-729. http://potency.berkeley.edu/CRCbook.html] or as overall "positive" by the EPA Gene-Tox Program [Kier et al. (1986) Mutat. Res. 168: 69-240]. All other chemicals evaluated for mutagenicity by these two sources are reported as "inactive". ActivityScore is assigned one of two values, 100=active; 0=inactive.
Comment
DSSTox CPDBAS: Carcinogenic Potency Database (CPDB) Summary Tables - All Species
To access complete SD file and documentation, refer to the DSSTox CPDBAS Download Page
For more information and description pertaining to this assay, and for access to the complete CPDB, see the Carcinogenic Potency Database website. For a full listing of Data Plots (from which the CPDB Summary Table was derived) see CPDB Data Plots. For a complete list of references, see CPDB Publications by Topic or CPDB Publications by Year.
Result Definitions
TIDNameDescriptionHistogramTypeUnit
OutcomeThe BioAssay activity outcomeOutcome
ScoreThe BioAssay activity ranking scoreInteger
1SingleCellCallAn assignment of carcinogenic categorical activity based on minimal evidence for or against activity. Activity Outcome "active" indicates one or more TD50 and tumor site listed for one or more carcinogenicity sex/species cell (e.g., Rat Male, Rat Female, Mouse Male, etc); "inactive" indicates no TD50 or tumor site listed AND one or more "no positive results" entry for one or more carcinogenicity experiment sex/species cell (i.e., one or more experiments are in CPDB, but none are positive); "unspecified" indicates that the only experiments in CPDB were conducted by the NCI/NTP, and the NCI/NTP evaluated the bioassay as inadequate. Associated TD50 values and tumor site details for the relevant species/sex experiment supporting this overall CPDB SingleSiteCall are provided in the full CPDBAS DSSTox file (see Comment) and the corresponding CPDB Species Bioassay in PubChem.String

Data Table (Concise)
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